食物成分对细胞色素P450表达及活性的影响

IF 1.8 Q3 ENDOCRINOLOGY & METABOLISM
Ruoyao Sang, Wenzhao Jiang, Cai Zhang, Runting Yin, Zhen Ouyang, Yuan Wei
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引用次数: 0

摘要

细胞色素p450 (CYPs)是血红蛋白超家族中的一个酶家族,在药物代谢中起着至关重要的作用。CYP活性和表达表现出相当大的个体差异。除遗传因素外,外部影响,如食物,可影响它们的活性和/或表达,从而影响由这些酶代谢的药物的功效和不良反应。随着食物种类和饮食模式的增加,食物在药物代谢中已成为越来越重要的因素。本文综述了各种食物对参与药物代谢的主要CYP亚型活性和表达的影响,为食品-药物相互作用提供新的认识,并为食用和药用植物的临床安全使用提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of food components on cytochrome P450 expression and activity
Cytochrome P450s (CYPs) are a family of enzymes within the hemoglobin superfamily that play a crucial role in drug metabolism. CYP activity and expression exhibit considerable individual variability. In addition to genetic factors, extrinsic influences, such as food, can affect their activity and/or expression, thereby impacting the efficacy and adverse effects of drugs metabolized by these enzymes. As food variety and diversity in dietary patterns increase, food has become an increasingly significant factor in drug metabolism. This review, summarizes the effects of various foods on the activity and expression of major CYP subtypes involved in drug metabolism, offering new insights into food-drug interactions and providing references for the safe clinical use of edible and medicinal plants.
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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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