肺标本分枝杆菌培养分离非结核分枝杆菌和诺卡菌

IF 2.1 4区 医学 Q3 INFECTIOUS DISEASES
Hongli Sun , Wenjing Liu , Lingli Liu , Xuefeng Sun
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引用次数: 0

摘要

非结核分枝杆菌(NTM)和诺卡菌通常通过分枝杆菌培养分离出来,但它们在各种肺标本中的患病率尚不确定。我们检索了2017年1月至2021年7月期间中国一家三级医院肺标本的分枝杆菌培养结果。非结核分枝杆菌(非结核分枝杆菌,包括NTM和诺卡菌)的流行率已超过结核分枝杆菌,占所有分离株结核分枝杆菌发病率的1.7倍。痰标本中非结核分枝杆菌阳性的频率明显高于支气管镜标本(3.7% vs 1.9%, P <;0.001)。此外,NTM占所有分枝杆菌分离株的59.8%,抗酸染色阳性患者占42.1%。多因素logistic回归分析发现,与结核分枝杆菌相比,与非结核分枝杆菌分离株显著相关的几个危险因素包括年龄超过45岁(调整优势比[aOR] 2.27)、支气管扩张(aOR 4.52)、肺间质性疾病(aOR 2.11)、慢性阻塞性肺疾病(aOR 1.94)和非糖尿病(aOR 2.10)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isolation of nontuberculous mycobacteria and Nocardia via mycobacterial culture from pulmonary specimens
Nontuberculous mycobacteria (NTM) and Nocardia are often isolated via mycobacterial culture, yet their prevalence in various pulmonary specimens is uncertain. We retrieved mycobacterial culture results from pulmonary specimens from a tertiary hospital in China between January 2017 and July 2021. The prevalence of non-Mycobacterium tuberculosis (non-Mtb, including NTM and Nocardia) has surpassed Mtb, accounting for 1.7 times the rate of Mtb among all isolates. The frequency of non-Mtb positivity in sputum specimens was significantly higher compared to that in bronchoscopy specimens (3.7% vs 1.9%, P < 0.001). Furthermore, NTM accounted for 59.8% of all Mycobacterium isolates and 42.1% of patients with positive acid-fast staining. Multivariate logistic regression analysis identified several risk factors significantly associated with non-Mtb isolates compared to Mtb, including age over 45 years (adjusted odds ratio [aOR] 2.27), bronchiectasis (aOR 4.52), pulmonary interstitial disorder (aOR 2.11), chronic obstructive pulmonary disease (aOR 1.94), and non-diabetes (aOR 2.10).
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来源期刊
CiteScore
5.30
自引率
3.40%
发文量
149
审稿时长
56 days
期刊介绍: Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.
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