实验室资源：单株细胞系-模板：从男性精神分裂症患者身上建立诱导多能干细胞（iPSC）细胞系（JNMUi003-A）

IF 0.8 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Stem cell research Pub Date : 2025-02-11 DOI:10.1016/j.scr.2025.103679

Yiliang Liu , Ran Li , Yuxing Long , Meixiang Jiang , Jingyi Xu , Tongyue Chi , Xiaohong Zhang , Hao Yu , Xiaobo Han

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引用次数: 0

摘要

我们使用非整合重编程技术，从一位41岁确诊为精神分裂症的男性患者的外周血单个核细胞中获得了诱导多能干细胞（iPSC）系。iPSC系表现出正常的核型，表达了多能性的特定标记，并在体外证明了向所有三种胚层分化的能力。该细胞系将作为一种有价值的体外模型，用于研究这种疾病的潜在病理生理机制和确定新的治疗方法。

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Lab resource: Single cell line – template: Establishment of an induced pluripotent stem cell (iPSC) line (JNMUi003-A) from a male patient with schizophrenia

We generated an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells obtained from a 41-year-old male patient diagnosed with schizophrenia using non-integrating reprogramming techniques. The iPSC lines exhibited normal karyotypes, expressed specific markers of pluripotency, and demonstrated the capacity to differentiate into all three germ layers in vitro. This cell line will serve as a valuable in vitro model for investigating the underlying pathophysiological mechanisms of this disease and identifying novel therapeutic approaches.

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来源期刊

Stem cell research 生物-生物工程与应用微生物

CiteScore

2.20

自引率

8.30%

发文量

338

审稿时长

55 days

期刊介绍： Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.