金属-有机骨架玻璃基手性固定相的制备及其对映体分离

IF 3.2 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Solid State Chemistry Pub Date : 2025-02-13 DOI:10.1016/j.jssc.2025.125252

Han Yang , Fu-Chang Liang , Bo Tang, Hai-Xiong Chen, Si-Yun Fu, Song-Liang Cai, Wei-Guang Zhang, Jun Fan, Sheng-Run Zheng

{"title":"金属-有机骨架玻璃基手性固定相的制备及其对映体分离","authors":"Han Yang , Fu-Chang Liang , Bo Tang, Hai-Xiong Chen, Si-Yun Fu, Song-Liang Cai, Wei-Guang Zhang, Jun Fan, Sheng-Run Zheng","doi":"10.1016/j.jssc.2025.125252","DOIUrl":null,"url":null,"abstract":"<div><div>The development of a chiral stationary phase (CSP) based on new matrices is still necessary because of the rapid growth of new chiral drugs and the limitations of the silica gel matrix. For the first time, MOF glass agZIF-62 was used as a matrix to fabricate a chiral stationary phase (CSP) by coating cellulose-tris(3,5-dimethylphenylcarbamate) (CDMPC). These MOF glass-based CSPs can separate various racemic compounds, including metalaxyl, epoxiconazole, TSO, <em>cis</em>-metconazole, and triticonazole with resolution values (Rs) ranging from 1.22 to 4.58 and separation factors (α) ranging from 1.8 to 6.79. In addition, the HPLC enantiomer separation performances of MOF glass-based and MOF crystal-based CSPs were compared.</div></div>","PeriodicalId":378,"journal":{"name":"Journal of Solid State Chemistry","volume":"346 ","pages":"Article 125252"},"PeriodicalIF":3.2000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Preparation of a metal‒organic framework glass‒based chiral stationary phase for HPLC enantiomer separation\",\"authors\":\"Han Yang , Fu-Chang Liang , Bo Tang, Hai-Xiong Chen, Si-Yun Fu, Song-Liang Cai, Wei-Guang Zhang, Jun Fan, Sheng-Run Zheng\",\"doi\":\"10.1016/j.jssc.2025.125252\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The development of a chiral stationary phase (CSP) based on new matrices is still necessary because of the rapid growth of new chiral drugs and the limitations of the silica gel matrix. For the first time, MOF glass agZIF-62 was used as a matrix to fabricate a chiral stationary phase (CSP) by coating cellulose-tris(3,5-dimethylphenylcarbamate) (CDMPC). These MOF glass-based CSPs can separate various racemic compounds, including metalaxyl, epoxiconazole, TSO, <em>cis</em>-metconazole, and triticonazole with resolution values (Rs) ranging from 1.22 to 4.58 and separation factors (α) ranging from 1.8 to 6.79. In addition, the HPLC enantiomer separation performances of MOF glass-based and MOF crystal-based CSPs were compared.</div></div>\",\"PeriodicalId\":378,\"journal\":{\"name\":\"Journal of Solid State Chemistry\",\"volume\":\"346 \",\"pages\":\"Article 125252\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-02-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Solid State Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022459625000751\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Solid State Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022459625000751","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}

引用次数: 0

摘要

由于新型手性药物的快速发展和硅胶基体的局限性，开发基于新基质的手性固定相（CSP）仍然是必要的。首次以MOF玻璃agZIF-62为基体，包覆纤维素-三（3,5-二甲基苯基氨基甲酸酯）（CDMPC）制备了手性固定相（CSP）。这些MOF玻璃基CSPs可分离甲酰基、环氧康唑、TSO、顺-甲康唑和三替康唑等外消旋化合物，分离值（Rs）为1.22 ~ 4.58，分离因子（α）为1.8 ~ 6.79。此外，还比较了MOF玻璃基csp和MOF晶体基csp的HPLC对映体分离性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Preparation of a metal‒organic framework glass‒based chiral stationary phase for HPLC enantiomer separation

查看原文本刊更多论文

Preparation of a metal‒organic framework glass‒based chiral stationary phase for HPLC enantiomer separation

The development of a chiral stationary phase (CSP) based on new matrices is still necessary because of the rapid growth of new chiral drugs and the limitations of the silica gel matrix. For the first time, MOF glass agZIF-62 was used as a matrix to fabricate a chiral stationary phase (CSP) by coating cellulose-tris(3,5-dimethylphenylcarbamate) (CDMPC). These MOF glass-based CSPs can separate various racemic compounds, including metalaxyl, epoxiconazole, TSO, cis-metconazole, and triticonazole with resolution values (Rs) ranging from 1.22 to 4.58 and separation factors (α) ranging from 1.8 to 6.79. In addition, the HPLC enantiomer separation performances of MOF glass-based and MOF crystal-based CSPs were compared.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Solid State Chemistry 化学-无机化学与核化学

CiteScore

6.00

自引率

9.10%

发文量

848

审稿时长

25 days

期刊介绍： Covering major developments in the field of solid state chemistry and related areas such as ceramics and amorphous materials, the Journal of Solid State Chemistry features studies of chemical, structural, thermodynamic, electronic, magnetic, and optical properties and processes in solids.