乳糜泻和COVID-19：利用卫生登记获得重要见解和公共卫生战略

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2025-02-14 DOI:10.1016/j.cegh.2025.101962

Beatrice Gasperini , Antonio Cherubini , Marco Pompili , Donatella Sarti , Emilia Prospero

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引用次数: 0

摘要

乳糜泻是一种由麸质引发的免疫介导的疾病，在遗传易感个体中，以存在特异性抗体和小肠炎症为特征。本研究旨在利用来自卫生登记处的行政数据，评估乳糜泻患者与普通人群相比感染SARS-CoV-2的风险和临床结果。方法本回顾性病例对照研究于2020年2月25日至2021年3月31日在意大利马尔切地区进行，使用乳糜泻登记处和意大利国家COVID-19监测系统。根据年龄、性别、居住地，采用倾向评分匹配（1:1）对乳糜泻患者和对照组进行比较。评估社会人口变量、慢性病、临床结果。结果4488例乳糜泻患者中，209例（4.65%,95% CI: 4.05 ~ 5.31%）感染COVID-19。乳糜泻组的感染率（4.65%）与非乳糜泻组相似（4.43%）（OR: 1.05, 95% CI: 0.91 ~ 1.21, p = 0.49）。7.2%的非乳糜泻患者和2.9%的乳糜泻患者住院（p = 0.015）。在倾向评分匹配后，417个人被纳入分析，结果显示两组之间的临床结果（包括住院和死亡率）没有显著差异(p >；0.05)。通过整合来自乳糜泻登记和COVID-19监测系统的数据，我们进行了全面的分析，与基于访谈的研究相比，以最小的资源投入提供了有价值的见解。研究结果表明，乳糜泻患者不需要额外的COVID-19预防措施，除了标准的公共卫生措施，支持使用登记处进行知情的医疗保健决策。

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Celiac disease and COVID-19: Leveraging health registries for crucial insights and public health strategies

Background

Celiac disease is an immune-mediated disorder triggered by gluten in genetically predisposed individuals, characterized by the presence of specific antibodies and inflammation of the small intestine. This study aims to assess the risk of SARS-CoV-2 infection and clinical outcomes among individuals with celiac disease compared to the general population using administrative data from health registries.

Methods

This retrospective case-control study was conducted in the Marche region, Italy, using the Celiac Disease Registry and the Italian National Monitoring System for COVID-19, from February 25, 2020, to March 31, 2021. Propensity score matching (1:1) was applied to compare celiac patients and controls based on age, sex, residence. Socio-demographic variables, chronic conditions, clinical outcomes were assessed.

Results

Among 4488 celiac patients, 209 (4.65 %, 95 % CI: 4.05–5.31 %) contracted COVID-19. The infection rate in the celiac group (4.65 %) was similar to that in the non-celiac (4.43 %) (OR: 1.05, 95 % CI: 0.91–1.21, p = 0.49). Hospitalizations occurred in 7.2 % of non-celiac patients and 2.9 % of celiac patients (p = 0.015). After propensity score matching, 417 individuals were included in the analysis, showing no significant differences in clinical outcomes, including hospitalization and mortality, between the groups (p > 0.05).

Conclusions

By integrating data from the Celiac Disease Registry and COVID-19 Monitoring System, we conducted a comprehensive analysis, providing valuable insights with minimal resource investment compared to interview-based studies. The findings suggest that celiac patients do not require additional COVID-19 precautions beyond standard public health measures, supporting the use of registries for informed healthcare decision-making.

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.