Xiangyu Chen , Yue Feng , Di Zhang , Shuiqing Zhou , Xinshuo Liu , Binghong Luo , Changren Zhou , Mingxian Liu
{"title":"口服含有polyphenol@halloysite粘土的水凝胶用于益生菌输送和治疗炎症性肠病","authors":"Xiangyu Chen , Yue Feng , Di Zhang , Shuiqing Zhou , Xinshuo Liu , Binghong Luo , Changren Zhou , Mingxian Liu","doi":"10.1016/j.nantod.2025.102669","DOIUrl":null,"url":null,"abstract":"<div><div>Oral medication treatment for inflammatory bowel disease (IBD) is often hindered by challenges such as low drug accumulation rates, limited penetration of mucus barriers, and suboptimal therapeutic efficacy. Here, we engineer a probiotic delivery platform (denominated as MHBSA) based on halloysite clay nanotubes (HNTs) to eliminate reactive oxygen species (ROS) and modulate the dysregulated gut microbiota for targeted treatment of IBD. HNTs are functionalized with the excellent adhesion activity and metal coordination ability of epigallocatechin gallate (MPN@HNTs), which are then incorporated into alginate microspheres to load probiotics. The alginate microspheres exhibit controlled release responsive to the intestinal microenvironment. MPN@HNTs is targeted to the inflamed colon sites through electrostatic interactions, and the rod-like microstructure of HNTs prolongs its retention time on the mucosa and enhances accumulation. MPN@HNTs not only reduces aberrantly activated immune responses by eliminating ROS but also improves the resistance of probiotics to oxidative stress. Surprisingly, upon oral administration, MHBSA modulates the gut microbiota, including restoring diversity and enhancing the abundance of short-chain fatty acid-related bacteria. Overall, the pH-responsive oral formulation containing medicinal clay and probiotics is a promising approach for IBD treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"62 ","pages":"Article 102669"},"PeriodicalIF":10.9000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Orally administered hydrogel containing polyphenol@halloysite clay for probiotic delivery and treatment of inflammatory bowel disease\",\"authors\":\"Xiangyu Chen , Yue Feng , Di Zhang , Shuiqing Zhou , Xinshuo Liu , Binghong Luo , Changren Zhou , Mingxian Liu\",\"doi\":\"10.1016/j.nantod.2025.102669\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Oral medication treatment for inflammatory bowel disease (IBD) is often hindered by challenges such as low drug accumulation rates, limited penetration of mucus barriers, and suboptimal therapeutic efficacy. Here, we engineer a probiotic delivery platform (denominated as MHBSA) based on halloysite clay nanotubes (HNTs) to eliminate reactive oxygen species (ROS) and modulate the dysregulated gut microbiota for targeted treatment of IBD. HNTs are functionalized with the excellent adhesion activity and metal coordination ability of epigallocatechin gallate (MPN@HNTs), which are then incorporated into alginate microspheres to load probiotics. The alginate microspheres exhibit controlled release responsive to the intestinal microenvironment. MPN@HNTs is targeted to the inflamed colon sites through electrostatic interactions, and the rod-like microstructure of HNTs prolongs its retention time on the mucosa and enhances accumulation. MPN@HNTs not only reduces aberrantly activated immune responses by eliminating ROS but also improves the resistance of probiotics to oxidative stress. Surprisingly, upon oral administration, MHBSA modulates the gut microbiota, including restoring diversity and enhancing the abundance of short-chain fatty acid-related bacteria. Overall, the pH-responsive oral formulation containing medicinal clay and probiotics is a promising approach for IBD treatment.</div></div>\",\"PeriodicalId\":395,\"journal\":{\"name\":\"Nano Today\",\"volume\":\"62 \",\"pages\":\"Article 102669\"},\"PeriodicalIF\":10.9000,\"publicationDate\":\"2025-02-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano Today\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1748013225000416\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1748013225000416","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Orally administered hydrogel containing polyphenol@halloysite clay for probiotic delivery and treatment of inflammatory bowel disease
Oral medication treatment for inflammatory bowel disease (IBD) is often hindered by challenges such as low drug accumulation rates, limited penetration of mucus barriers, and suboptimal therapeutic efficacy. Here, we engineer a probiotic delivery platform (denominated as MHBSA) based on halloysite clay nanotubes (HNTs) to eliminate reactive oxygen species (ROS) and modulate the dysregulated gut microbiota for targeted treatment of IBD. HNTs are functionalized with the excellent adhesion activity and metal coordination ability of epigallocatechin gallate (MPN@HNTs), which are then incorporated into alginate microspheres to load probiotics. The alginate microspheres exhibit controlled release responsive to the intestinal microenvironment. MPN@HNTs is targeted to the inflamed colon sites through electrostatic interactions, and the rod-like microstructure of HNTs prolongs its retention time on the mucosa and enhances accumulation. MPN@HNTs not only reduces aberrantly activated immune responses by eliminating ROS but also improves the resistance of probiotics to oxidative stress. Surprisingly, upon oral administration, MHBSA modulates the gut microbiota, including restoring diversity and enhancing the abundance of short-chain fatty acid-related bacteria. Overall, the pH-responsive oral formulation containing medicinal clay and probiotics is a promising approach for IBD treatment.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.