口服含有polyphenol@halloysite粘土的水凝胶用于益生菌输送和治疗炎症性肠病

IF 10.9 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Xiangyu Chen , Yue Feng , Di Zhang , Shuiqing Zhou , Xinshuo Liu , Binghong Luo , Changren Zhou , Mingxian Liu
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引用次数: 0

摘要

炎症性肠病(IBD)的口服药物治疗经常受到药物积累率低、粘液屏障渗透有限和治疗效果欠佳等挑战的阻碍。在这里,我们设计了一个基于高岭土粘土纳米管(HNTs)的益生菌递送平台(命名为MHBSA),以消除活性氧(ROS)并调节失调的肠道微生物群,以靶向治疗IBD。HNTs具有出色的粘附活性和表没食子儿茶素没食子酸酯的金属配位能力(MPN@HNTs),然后将其纳入海藻酸微球中以装载益生菌。海藻酸盐微球对肠道微环境具有控释反应。MPN@HNTs通过静电相互作用靶向发炎的结肠部位,HNTs的杆状微观结构延长了其在粘膜上的滞留时间,促进了积累。MPN@HNTs不仅通过消除ROS减少异常激活的免疫反应,而且还提高了益生菌对氧化应激的抵抗力。令人惊讶的是,口服后,MHBSA调节肠道微生物群,包括恢复多样性和提高短链脂肪酸相关细菌的丰度。总的来说,含有药用粘土和益生菌的ph响应口服制剂是治疗IBD的一种很有前途的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Orally administered hydrogel containing polyphenol@halloysite clay for probiotic delivery and treatment of inflammatory bowel disease
Oral medication treatment for inflammatory bowel disease (IBD) is often hindered by challenges such as low drug accumulation rates, limited penetration of mucus barriers, and suboptimal therapeutic efficacy. Here, we engineer a probiotic delivery platform (denominated as MHBSA) based on halloysite clay nanotubes (HNTs) to eliminate reactive oxygen species (ROS) and modulate the dysregulated gut microbiota for targeted treatment of IBD. HNTs are functionalized with the excellent adhesion activity and metal coordination ability of epigallocatechin gallate (MPN@HNTs), which are then incorporated into alginate microspheres to load probiotics. The alginate microspheres exhibit controlled release responsive to the intestinal microenvironment. MPN@HNTs is targeted to the inflamed colon sites through electrostatic interactions, and the rod-like microstructure of HNTs prolongs its retention time on the mucosa and enhances accumulation. MPN@HNTs not only reduces aberrantly activated immune responses by eliminating ROS but also improves the resistance of probiotics to oxidative stress. Surprisingly, upon oral administration, MHBSA modulates the gut microbiota, including restoring diversity and enhancing the abundance of short-chain fatty acid-related bacteria. Overall, the pH-responsive oral formulation containing medicinal clay and probiotics is a promising approach for IBD treatment.
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来源期刊
Nano Today
Nano Today 工程技术-材料科学:综合
CiteScore
21.50
自引率
3.40%
发文量
305
审稿时长
40 days
期刊介绍: Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.
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