一种新的二聚倍半萜类化合物

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-16 DOI:10.1016/j.phytol.2025.02.001

Xiaoran Min , Junping Chen , Wenhao Mu , Jiayi Huang , Guozheng Huang , Jianguo Cao

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引用次数: 0

摘要

从水仙的地上部分分离得到1个新的倍半萜类化合物(1)和18个已知的天然化合物（2 ~ 19）。通过光谱方法确定了它们的结构，并通过单晶x射线衍射分析进一步确定了化合物1和3的绝对构型。化合物1是一种愈创木酚类二聚倍半萜类化合物，可能是化合物3与其1,2-脱水类似物[4 + 2]加成反应的产物。化合物12具有较强的黄嘌呤氧化酶（XOD）抑制活性（IC50值为23.82 ± 0.35 μM），为混合型XOD抑制剂。化合物12和13表现出低毒性，同时显著抑制lps诱导的RAW264.7细胞NO的产生。

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A new dimeric sesquiterpenoid from Ajania fruticulosa

One new sesquiterpenoid (1) and eighteen known natural compounds (2–19) were obtained from the aerial parts of Ajania fruticulosa. Their structures were established by spectroscopic methods, and the absolute configurations were further determined by single-crystal X-ray diffraction analysis for compounds 1 and 3. Compound 1 is a guaianolide-type dimeric sesquiterpenoid which might be a product of [4 + 2] addition reaction between compound 3 and its 1,2-dehydro analogue. Compound 12 showed a potent xanthine oxidase (XOD) inhibitory activity (IC₅₀ value of 23.82 ± 0.35 μM) and acted as a mixed-type inhibitor of XOD. Compounds 12 and 13 showed low toxicity while significantly inhibiting LPS-induced NO production in RAW264.7 cells.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.