半乳甘露聚糖检测的罕见病例：及时诊断和处理青花葵引起的腹膜透析腹膜炎

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports Pub Date : 2025-02-11 DOI:10.1016/j.mmcr.2025.100697

Baramett Somtha , Kanjana Tianprasertkij , Supattra Promngam , Thunvarat Saejew , Talerngsak Kanjanabuch

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引用次数: 0

摘要

真菌性腹膜炎在腹膜透析（PD）提出了重大挑战。我们报告一名53岁男性的第二例黄斑线虫相关的PD腹膜炎。PD排出液（PDE）和血清中半乳甘露聚糖（GM）指数均呈阳性（0.65）和阴性（0.98），提示PD导管在第5天早期拔除。分子测序证实了Q. cyanescens，其抗真菌药敏试验显示对唑类和棘白菌素耐药，但对两性霉素B和异唑康唑敏感。两性霉素B和伏立康唑治疗可缓解症状，在两年随访期间无复发。该病例强调了GM检测在指导导管移除和遵守2022 ISPD腹膜炎指南方面的关键作用，确保罕见的真菌性PD感染的良好预后。

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Timely diagnosis and management of Quambalaria cyanescens-induced peritoneal dialysis peritonitis: A rare case highlighting the role of galactomannan testing

Fungal peritonitis in peritoneal dialysis (PD) presents significant challenges. We report the second Quambalaria cyanescens-related PD peritonitis in a 53-year-old male. Negative bacterial cultures and a positive galactomannan (GM) index in both PD effluent (PDE) (0.65) and serum (0.98) prompted early PD catheter removal on day 5. Molecular sequencing confirmed Q. cyanescens, with antifungal susceptibility testing revealing resistance to azoles and echinocandins but susceptibility to amphotericin B and isavuconazonium. Treatment with amphotericin B and voriconazole resolved symptoms, with no relapses during a two-year follow-up. This case highlights GM testing's critical role in guiding catheter removal and adherence to the 2022 ISPD Peritonitis Guidelines, ensuring favorable outcomes for rare fungal PD infections.

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来源期刊

Medical Mycology Case Reports MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

47 days