炔烃的区域选择性形式氢酰胺化：α-取代的丙烯酰胺的合成

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-04-23 DOI:10.1002/ejoc.202401484

Cheong Hoon Park , Seeun Lim , Prof. Dr. Byunghyuck Jung , Prof. Dr. Yunmi Lee

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引用次数: 0

摘要

炔的形式氢酰胺化是一种强大的合成方法，可以形成各种α，β‐不饱和酰胺。在本文中，描述了末端和内部炔的高效形式氢酰胺化，这构成了Ni催化的α选择性炔的氢铝化和随后的异氰酸酯处理。该方法是克级可扩展的，其合成用途是由α -苯基丙烯酰胺合成β -内酰胺。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Regioselective Formal Hydroamidation of Alkynes: Synthesis of α‐Substituted Acrylamides

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Regioselective Formal Hydroamidation of Alkynes: Synthesis of α‐Substituted Acrylamides

The formal hydroamidation of alkyne is a powerful synthetic method that enables the formation of various α,β‐unsaturated amides. In this article, the efficient formal hydroamidation of terminal and internal alkynes is described, which constitutes the Ni‐catalyzed α‐selective hydroalumination of alkynes and subsequent treatment with isocyanates. This method is gram‐scalable and the synthetic utility is highlighted by the synthesis of a β‐lactam from α‐phenyl acrylamide.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.