通过生长素受体治疗癌症恶病质的个性化药物

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2025-02-14 DOI:10.1038/s41594-025-01496-7

Meng Zhang, Yaxu Wang, M. Madan Babu

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引用次数: 0

摘要

ghrelin受体（GHSR1a）是治疗癌症恶病质的关键靶点。现在一项研究揭示了与获批药物anamorelin结合的GHSR1a-miniGq复合物的结构，为超激动作用在癌症恶病质治疗中的作用提供了新的见解。这项综合研究为个性化治疗策略提供了框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Personalized medicine for cancer cachexia via the ghrelin receptor

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Personalized medicine for cancer cachexia via the ghrelin receptor

The ghrelin receptor (GHSR1a) is a key target for treating cancer cachexia. A study now reveals the structure of the GHSR1a–miniGq complex bound to the approved drug anamorelin, providing insights into the role of superagonism in cancer cachexia therapy. The comprehensive study represents a framework for personalized treatment strategies.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.