Michael Ahdoot, Aurash Naser-Tavakolian, John R Heard, Cheyenne Williams, Michael Daneshvar, Patrick Gomella, Samhita Mallavarapu, Minhaj Siddiqui, Michael Nazmifar, Joanna Shih, Baris Turkbey, Bradford Wood, Peter Pinto
{"title":"PSA密度选择MRI靶向与联合活检诊断前列腺癌:三重奏研究的二次分析。","authors":"Michael Ahdoot, Aurash Naser-Tavakolian, John R Heard, Cheyenne Williams, Michael Daneshvar, Patrick Gomella, Samhita Mallavarapu, Minhaj Siddiqui, Michael Nazmifar, Joanna Shih, Baris Turkbey, Bradford Wood, Peter Pinto","doi":"10.1097/JU.0000000000004480","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The addition of systematic prostate biopsy enhances the detection of clinically significant prostate cancer compared with MRI-targeted biopsy alone. However, there is growing interest in using only MRI-targeted biopsy. We sought to evaluate PSA density (PSAD) as an adjunctive predictor of clinically significant prostate cancer detection in men undergoing combined biopsy and as a potential metric to stratify which patients may reasonably avoid systematic biopsies in favor of MRI-targeted biopsy only.</p><p><strong>Materials and methods: </strong>Men with elevated PSA and/or abnormal digital rectal examination found to have an MRI-visible prostate lesion underwent MRI-targeted and systematic prostate biopsy. Primary outcomes were clinically significant cancer detection rates by MRI-targeted, systematic biopsy, and combined biopsy across 4 discrete PSAD intervals (<0.1, <u>≥</u>0.1 and <0.15, <u>≥</u>0.15 and <0.2, and <u>≥</u>0.2 ng/mL/cm<sup>3</sup>). Secondary outcomes were the added value of systematic biopsy relative to MRI-targeted biopsy alone.</p><p><strong>Results: </strong>Among men with Prostate Imaging Reporting and Data System <u>≥</u> 2 lesions, as PSAD surpassed each interval, the rate of grade group <u>≥</u> 3 cancer detection approximately doubled (<0.1: 9.3%, <u>≥</u>0.1 and <0.15: 18.2%, <u>≥</u>0.15 and <0.2: 36%, and <u>≥</u>0.2: 61.2%). For PSAD <u>≥</u> 0.2, added detection of clinically significant cancer with systematic biopsy was low (2%, 95% CI: 0.4%-5.9%).</p><p><strong>Conclusions: </strong>Given an approximate doubling in grade group <u>≥</u> 3 cancer detection on combined biopsy with rising PSAD intervals, clinicians may consider PSAD in risk stratifying men at high risk of clinically significant prostate cancer. Clinicians may consider omitting systematic biopsy for targeted biopsy of MRI-visible lesions in patients with PSAD <u>≥</u> 0.2 ng/mL/cm<sup>3</sup>, as systematic biopsy results in low rates of additional clinically significant cancer detection.</p>","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"693-701"},"PeriodicalIF":5.9000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prostate-Specific Antigen Density to Select Magnetic Resonance Imaging-Targeted vs Combined Biopsy for Prostate Cancer Diagnosis: A Secondary Analysis of the Trio Study.\",\"authors\":\"Michael Ahdoot, Aurash Naser-Tavakolian, John R Heard, Cheyenne Williams, Michael Daneshvar, Patrick Gomella, Samhita Mallavarapu, Minhaj Siddiqui, Michael Nazmifar, Joanna Shih, Baris Turkbey, Bradford Wood, Peter Pinto\",\"doi\":\"10.1097/JU.0000000000004480\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The addition of systematic prostate biopsy enhances the detection of clinically significant prostate cancer compared with MRI-targeted biopsy alone. However, there is growing interest in using only MRI-targeted biopsy. We sought to evaluate PSA density (PSAD) as an adjunctive predictor of clinically significant prostate cancer detection in men undergoing combined biopsy and as a potential metric to stratify which patients may reasonably avoid systematic biopsies in favor of MRI-targeted biopsy only.</p><p><strong>Materials and methods: </strong>Men with elevated PSA and/or abnormal digital rectal examination found to have an MRI-visible prostate lesion underwent MRI-targeted and systematic prostate biopsy. Primary outcomes were clinically significant cancer detection rates by MRI-targeted, systematic biopsy, and combined biopsy across 4 discrete PSAD intervals (<0.1, <u>≥</u>0.1 and <0.15, <u>≥</u>0.15 and <0.2, and <u>≥</u>0.2 ng/mL/cm<sup>3</sup>). Secondary outcomes were the added value of systematic biopsy relative to MRI-targeted biopsy alone.</p><p><strong>Results: </strong>Among men with Prostate Imaging Reporting and Data System <u>≥</u> 2 lesions, as PSAD surpassed each interval, the rate of grade group <u>≥</u> 3 cancer detection approximately doubled (<0.1: 9.3%, <u>≥</u>0.1 and <0.15: 18.2%, <u>≥</u>0.15 and <0.2: 36%, and <u>≥</u>0.2: 61.2%). For PSAD <u>≥</u> 0.2, added detection of clinically significant cancer with systematic biopsy was low (2%, 95% CI: 0.4%-5.9%).</p><p><strong>Conclusions: </strong>Given an approximate doubling in grade group <u>≥</u> 3 cancer detection on combined biopsy with rising PSAD intervals, clinicians may consider PSAD in risk stratifying men at high risk of clinically significant prostate cancer. Clinicians may consider omitting systematic biopsy for targeted biopsy of MRI-visible lesions in patients with PSAD <u>≥</u> 0.2 ng/mL/cm<sup>3</sup>, as systematic biopsy results in low rates of additional clinically significant cancer detection.</p>\",\"PeriodicalId\":17471,\"journal\":{\"name\":\"Journal of Urology\",\"volume\":\" \",\"pages\":\"693-701\"},\"PeriodicalIF\":5.9000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Urology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/JU.0000000000004480\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/JU.0000000000004480","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/14 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Prostate-Specific Antigen Density to Select Magnetic Resonance Imaging-Targeted vs Combined Biopsy for Prostate Cancer Diagnosis: A Secondary Analysis of the Trio Study.
Purpose: The addition of systematic prostate biopsy enhances the detection of clinically significant prostate cancer compared with MRI-targeted biopsy alone. However, there is growing interest in using only MRI-targeted biopsy. We sought to evaluate PSA density (PSAD) as an adjunctive predictor of clinically significant prostate cancer detection in men undergoing combined biopsy and as a potential metric to stratify which patients may reasonably avoid systematic biopsies in favor of MRI-targeted biopsy only.
Materials and methods: Men with elevated PSA and/or abnormal digital rectal examination found to have an MRI-visible prostate lesion underwent MRI-targeted and systematic prostate biopsy. Primary outcomes were clinically significant cancer detection rates by MRI-targeted, systematic biopsy, and combined biopsy across 4 discrete PSAD intervals (<0.1, ≥0.1 and <0.15, ≥0.15 and <0.2, and ≥0.2 ng/mL/cm3). Secondary outcomes were the added value of systematic biopsy relative to MRI-targeted biopsy alone.
Results: Among men with Prostate Imaging Reporting and Data System ≥ 2 lesions, as PSAD surpassed each interval, the rate of grade group ≥ 3 cancer detection approximately doubled (<0.1: 9.3%, ≥0.1 and <0.15: 18.2%, ≥0.15 and <0.2: 36%, and ≥0.2: 61.2%). For PSAD ≥ 0.2, added detection of clinically significant cancer with systematic biopsy was low (2%, 95% CI: 0.4%-5.9%).
Conclusions: Given an approximate doubling in grade group ≥ 3 cancer detection on combined biopsy with rising PSAD intervals, clinicians may consider PSAD in risk stratifying men at high risk of clinically significant prostate cancer. Clinicians may consider omitting systematic biopsy for targeted biopsy of MRI-visible lesions in patients with PSAD ≥ 0.2 ng/mL/cm3, as systematic biopsy results in low rates of additional clinically significant cancer detection.
期刊介绍:
The Official Journal of the American Urological Association (AUA), and the most widely read and highly cited journal in the field, The Journal of Urology® brings solid coverage of the clinically relevant content needed to stay at the forefront of the dynamic field of urology. This premier journal presents investigative studies on critical areas of research and practice, survey articles providing short condensations of the best and most important urology literature worldwide, and practice-oriented reports on significant clinical observations.