是时候用Adropin的生理维度拓宽心血管疾病的药理学治疗了。

IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Sana Akhlaq
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引用次数: 0

摘要

Adropin是一种新兴物质,因其具有保护心脏的潜力而受到欢迎,它为对抗心血管疾病提供了一条有希望的途径。当前的叙述性综述计划强调其与代谢综合征的联系及其在预防缺血性心脏病中的作用,强调其对代谢和心脏健康的多方面影响。从机制上讲,它通过多种途径起作用,包括调节内皮一氧化氮合酶、抗凋亡特性和调节丙酮酸脱氢酶磷酸化,以促进细胞能量产生和线粒体功能。此外,它与细胞受体、信号级联和代谢调节因子的相互作用揭示了它在减轻心血管风险和加强血糖控制方面的强大功能。为了将adropin从实验室过渡到临床,必须进行严格的人体试验,包括剂量优化、长期安全性评估和基因影响的探索。针对不同人群的包容性研究,特别是高风险人群,提倡揭示其全部治疗潜力。跨学科合作对于揭示其作为心血管疾病靶向治疗的机制至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Time to broaden pharmacological treatment of cardiovascular disorders with physiological dimensions of Adropin.

Adropin, an emerging substance hailed for its heartprotective potential, presents a promising avenue for combating cardiovascular ailments. The current narrative review was planned to underscore its link with metabolic syndrome and its role in preventing ischaemic heart disease, accentuating its multifaceted impact on metabolism and cardiac wellbeing. Mechanistically, it operates through diverse pathways, including modulation of endothelial nitric oxide synthase, antiapoptotic properties, and regulation of pyruvate dehydrogenase phosphorylation to boost cellular energy production and mitochondrial function. Furthermore, its interactions with cellular receptors, signalling cascades and metabolic regulators unveil its prowess in mitigating cardiovascular risks and enhancing glycaemic control. To transition adropin from bench to bedside, rigorous human trials are imperative, encompassing dose optimisation, long-term safety assessments, and exploration of genetic influences. Inclusive research targetting diverse populations, especially high-risk cohorts, is advocated to unravel its full therapeutic potential. Interdisciplinary collaboration is pivotal for unravelling its mechanisms as a targetted therapy for cardiovascular disorders.

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来源期刊
CiteScore
1.10
自引率
11.10%
发文量
983
审稿时长
3-6 weeks
期刊介绍: Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.
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