肥胖2型糖尿病患者代谢手术与强化药物治疗的短期疗效:一项准实验研究

IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Zahra Raza, Muhammad Burhan Ul Haq, Tashfeen Imtiaz, Muhammad Adnan Khokhar, Aatif Inam
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引用次数: 0

摘要

目的:比较肥胖症合并2型糖尿病患者行代谢手术与强化内科治疗的近期疗效。方法:准实验研究于2018年3月至2019年2月在巴基斯坦伊斯兰堡巴基斯坦医学科学研究所进行,研究对象为20-65岁的肥胖2型糖尿病患者,男女不限。接受代谢和减肥手术的患者为A组,接受强化药物治疗的患者为b组。所有患者随访6个月,监测代谢情况,包括体重指数、糖化血红蛋白和空腹血糖。数据采用SPSS 20进行分析。结果:72例患者中,A组36例(50%);女性23例(63.9%),男性13例(36.1%),平均年龄(41.2±10.2)岁。其余36例(50%)患者为B组;男性22例(61.1%),女性14例(38.9%),平均年龄42.5±10.6岁(p < 0.05)。6个月时,与B组相比,A组的平均体重指数、糖化血红蛋白和空腹血糖值显著降低(结论:减肥手术在肥胖人群糖尿病管理中产生了良好的早期结果,导致术后缓解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Short-term outcome of metabolic surgery versus intensive medical therapy among obese type 2 diabetics: a quasi-experimental study.

Objective: To compare the short-term outcomes of metabolic surgery and intensive medical therapy in the management of diabetes mellitus among obese persons with type 2 diabetes mellitus.

Methods: The quasi-experimental study was conducted at the Pakistan Institute of Medical Sciences, Islamabad, Pakistan, from March 2018 to February 2019, and comprised obese type 2 diabetes mellitus patients of either gender aged 20-65 years. Those undergoing metabolic and bariatric surgery were assigned group A, while those undergoing intensive medical therapy formed control group B. All patients were followed up for 6 months to monitor their metabolic profile, including body mass index, glycosylated haemoglobin and fasting plasma glucose. Data was analysed using SPSS 20.

Results: Of the 72 patients, 36(50%) were in group A; 23(63.9%) females and 13(36.1%) males with mean age 41.2 ± 10.2 years. The remaining 36(50%) patients were in group B; 22(61.1%) males and 14(38.9%) females with mean age 42.5 ± 10.6 years (p>0.05). At 6 months, mean body mass index, glycosylated haemoglobin and fasting plasma glucose values were significantly lower in group A compared to group B (p<0.001). There were 33(91.7%) patients in group A with remission of diabetes compared to 1(2.8%) patients in group B (p<0.001).

Conclusions: Bariatric surgery was found to produce a good early outcome in the management of diabetes in the obese population, leading to remission post-surgery.

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来源期刊
CiteScore
1.10
自引率
11.10%
发文量
983
审稿时长
3-6 weeks
期刊介绍: Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.
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