{"title":"结直肠癌患者围手术期生活质量的变化及术前生活质量对术后重返工作时间的影响：一项前瞻性、多中心、队列研究","authors":"Yusuke Fujita, Koya Hida, Tatsuto Nishigori, Shinya Hamasu, Tetsuya Shiota, Takatsugu Kan, Ryosuke Okamura, Yoshiro Itatani, Kazutaka Obama","doi":"10.1007/s00595-025-03012-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated perioperative changes in quality of life (QOL) and the impact of preoperative QOL on the time to return to work (RTW) after surgery in patients with colorectal cancer.</p><p><strong>Methods: </strong>Patients with clinical stage I-III colorectal cancer who were employed at the diagnosis and scheduled for curative surgery between 2019 and 2020 were prospectively enrolled at 7 hospitals in Japan. The patients' EORTC-QLQ-C30 scores and employment status were collected before and at 6 and 12 months after surgery and compared using a paired t test. The Kaplan-Meier method and multivariable Cox regression model were applied to examine the impact of preoperative QOL on the time to RTW.</p><p><strong>Results: </strong>A total of 127 patients were analyzed. Regarding financial difficulties, 48% of patients had low preoperative scores, which significantly improved at 6 (preoperatively: 21.7 vs 6 months: 11.3; p < 0.001) and 12 months (6 months: 11.3; 12 months: 7.9; p = 0.016) postoperatively. RTW was significantly delayed in patients with a low preoperative cognitive function (p = 0.039) and severe fatigue (p = 0.024). The adjusted hazard ratio was 0.73 for a low cognitive function and 0.62 for strong fatigue.</p><p><strong>Conclusion: </strong>Working patients with colorectal cancer experienced severe financial difficulties preoperatively, which decreased postoperatively. The preoperative cognitive function and fatigue affected the postoperative time to RTW.</p>","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"760-767"},"PeriodicalIF":1.7000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Perioperative changes in the quality of life and the impact of preoperative quality of life on the time to return to work after surgery among patients with colorectal cancer: a prospective, multicenter, cohort study.\",\"authors\":\"Yusuke Fujita, Koya Hida, Tatsuto Nishigori, Shinya Hamasu, Tetsuya Shiota, Takatsugu Kan, Ryosuke Okamura, Yoshiro Itatani, Kazutaka Obama\",\"doi\":\"10.1007/s00595-025-03012-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study investigated perioperative changes in quality of life (QOL) and the impact of preoperative QOL on the time to return to work (RTW) after surgery in patients with colorectal cancer.</p><p><strong>Methods: </strong>Patients with clinical stage I-III colorectal cancer who were employed at the diagnosis and scheduled for curative surgery between 2019 and 2020 were prospectively enrolled at 7 hospitals in Japan. The patients' EORTC-QLQ-C30 scores and employment status were collected before and at 6 and 12 months after surgery and compared using a paired t test. The Kaplan-Meier method and multivariable Cox regression model were applied to examine the impact of preoperative QOL on the time to RTW.</p><p><strong>Results: </strong>A total of 127 patients were analyzed. Regarding financial difficulties, 48% of patients had low preoperative scores, which significantly improved at 6 (preoperatively: 21.7 vs 6 months: 11.3; p < 0.001) and 12 months (6 months: 11.3; 12 months: 7.9; p = 0.016) postoperatively. RTW was significantly delayed in patients with a low preoperative cognitive function (p = 0.039) and severe fatigue (p = 0.024). The adjusted hazard ratio was 0.73 for a low cognitive function and 0.62 for strong fatigue.</p><p><strong>Conclusion: </strong>Working patients with colorectal cancer experienced severe financial difficulties preoperatively, which decreased postoperatively. The preoperative cognitive function and fatigue affected the postoperative time to RTW.</p>\",\"PeriodicalId\":22163,\"journal\":{\"name\":\"Surgery Today\",\"volume\":\" \",\"pages\":\"760-767\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Surgery Today\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00595-025-03012-2\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surgery Today","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00595-025-03012-2","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/13 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
摘要
目的：探讨结直肠癌患者围手术期生活质量（QOL）的变化及术前生活质量对术后重返工作时间（RTW）的影响。方法：前瞻性纳入日本7家医院2019 - 2020年诊断并计划进行根治性手术的临床I-III期结直肠癌患者。收集患者术前、术后6个月和12个月的EORTC-QLQ-C30评分和就业状况，采用配对t检验进行比较。应用Kaplan-Meier法和多变量Cox回归模型检验术前生活质量对RTW时间的影响。结果：共分析127例患者。在经济困难方面，48%的患者术前评分较低，6个月时明显改善(术前：21.7 vs 6个月：11.3；结论：结直肠癌工作患者术前经济困难严重，术后经济困难减少。术前认知功能和疲劳程度影响术后转位时间。
Perioperative changes in the quality of life and the impact of preoperative quality of life on the time to return to work after surgery among patients with colorectal cancer: a prospective, multicenter, cohort study.
Purpose: This study investigated perioperative changes in quality of life (QOL) and the impact of preoperative QOL on the time to return to work (RTW) after surgery in patients with colorectal cancer.
Methods: Patients with clinical stage I-III colorectal cancer who were employed at the diagnosis and scheduled for curative surgery between 2019 and 2020 were prospectively enrolled at 7 hospitals in Japan. The patients' EORTC-QLQ-C30 scores and employment status were collected before and at 6 and 12 months after surgery and compared using a paired t test. The Kaplan-Meier method and multivariable Cox regression model were applied to examine the impact of preoperative QOL on the time to RTW.
Results: A total of 127 patients were analyzed. Regarding financial difficulties, 48% of patients had low preoperative scores, which significantly improved at 6 (preoperatively: 21.7 vs 6 months: 11.3; p < 0.001) and 12 months (6 months: 11.3; 12 months: 7.9; p = 0.016) postoperatively. RTW was significantly delayed in patients with a low preoperative cognitive function (p = 0.039) and severe fatigue (p = 0.024). The adjusted hazard ratio was 0.73 for a low cognitive function and 0.62 for strong fatigue.
Conclusion: Working patients with colorectal cancer experienced severe financial difficulties preoperatively, which decreased postoperatively. The preoperative cognitive function and fatigue affected the postoperative time to RTW.
期刊介绍：
Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it").
The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.
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