Dan-Lin Li, Min-Xin Liu, Ya-Jie Zheng, Yu Qin, Rong Ma, Gang Liang, Chen-Wei Pan
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引用次数: 0
摘要
目的：探讨健康青壮年血清生化指标与角膜生物力学的关系。方法：选取健康大学生1645名。每个学生都接受了Corvis ST眼科检查以测量角膜生物力学，并进行了血液检查以评估丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、尿素、肌酐和尿酸（UA）水平。采用典型相关分析（CCA）评价两者的关系。结果：无论男女，血清生化指标与角膜生物力学均存在显著相关性。对于男性，典型相关性确定了第一次压平时间（A1t）、第二次压平时间（A2t）、最大凹度时间（HC-t）、最大凹度挠度幅度（HC-DeflA）和生物力学校正眼压（bIOP）与ALT、AST、尿素和UA之间的相关性（r = 0.235, P = 0.03）。对于女性，A1t、A2t和bIOP与ALT和UA之间存在显著相关性（r = 0.187, P < 0.01）。结论：ALT和UA水平升高与角膜更柔软、弹性和粘性更大有关。本研究为血清生化指标与眼部变化之间的关系提供了新的证据。转化相关性：这些发现可以帮助临床医生在对肝脏或肾脏疾病患者进行角膜手术时进行充分的术前评估，也可以帮助公共卫生从业人员了解健康人角膜变化的血清生化变量。
The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults.
Purpose: To investigate the relationship between serum biochemical variables and corneal biomechanics in healthy young adults.
Methods: A total of 1645 healthy university students were included. Every student underwent an ophthalmologic examination by Corvis ST to measure the corneal biomechanics and a blood examination to evaluate the alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, creatinine, and uric acid (UA) levels. Canonical correlation analysis (CCA) was conducted to assess their relationship.
Results: A significant relationship between serum biochemical variables and corneal biomechanics was found in both men and women. For men, the canonical correlation identified an association between the time of the first applanation (A1t), time of the second applanation (A2t), time of the highest concavity (HC-t), deflection amplitude of the highest concavity (HC-DeflA), and biomechanically corrected intraocular pressure (bIOP) with ALT, AST, urea, and UA (r = 0.235, P = 0.03). For women, a significant relationship between A1t, A2t, and bIOP with ALT and UA was found (r = 0.187, P < 0.01).
Conclusions: Elevated levels of ALT and UA were associated with softer corneas with greater elasticity and viscidity. The study provides novel evidence for the relationship between serum biochemical variables and ocular changes.
Translational relevance: These findings may help clinicians perform adequate preoperative evaluations when performing corneal surgery on patients with liver or kidney disorders, as well as helping public health practitioners understand serum biochemical variables of corneal changes in healthy people.
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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