硒暴露与中老年人胰岛素抵抗和β细胞功能的差异关联。

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Zulema Rodriguez-Hernandez, Javier Bel-Aguilar, Belen Moreno-Franco, Maria Grau-Perez, Josep Redon, Jose L Gomez-Ariza, Tamara Garcia-Barrera, Pablo Olmedo, Fernando Gil, Ana Cenarro, Fernando Civeira, Jose Puzo, Jose A Casasnovas, Jose R Banegas, Mercedes Sotos-Prieto, Rosario Ortola, Martin Laclaustra, Fernando Rodriguez-Artalejo, Esther Garcia-Esquinas, Maria Tellez-Plaza, Roberto Pastor-Barriuso
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引用次数: 0

摘要

目的:评估硒对糖尿病前期的作用是否因年龄、合并症和老年人β细胞功能下降而不同。研究设计和方法:我们评估了血硒与中年人(阿拉贡工人健康研究[AWHS], N = 1186)和老年人(ENRICA[西班牙营养和心血管风险研究]-2 [SEN-2], N = 915)无糖尿病成年人胰岛素抵抗(HOMA- ir)和β细胞功能(HOMA-β)稳态模型评估的横断关联。来自AWHS (N = 571)和SEN-2 (N = 603)的参与者亚样本进行了葡萄糖和胰岛素的重复测量,用于纵向分析。我们在2011-2018年全国健康与营养检查调查(NHANES, N = 1317名中年和N = 960名老年人)参与者中验证了横断面剂量-反应关联。采用ICP-MS法测定AWHS、SEN-2和NHANES全血中硒含量。结果:AWHS中HOMA- ir和HOMA-β每增加2倍硒的横截面几何平均比值(95%置信区间)分别为1.09(1.01,1.19)和1.15 (1.06,1.24);SEN-2分别为1.13(0.98、1.31)和1.03(0.90、1.18)。在NHANES中,横断面剂量-反应关联是一致的,在年轻人中,两个HOMA终点大多呈上升趋势,在老年人中,在水平为bb0 ~150 μg/L时呈平台期。在年轻的研究人群中,高硒剂量对两个HOMA终点的纵向剂量反应一致显示出正相关,而在老年研究人群中则没有。结论:血硒的增加与中年人胰岛素抵抗和β细胞功能的增加有关,但与老年人无关,特别是与β细胞功能无关。结果表明,硒相关的胰岛素抵抗可能在年轻时诱导代偿性β细胞功能增加,因为这种代偿能力随着年龄的增长而下降。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Differential association of selenium exposure with insulin resistance and β-cell function in middle age and older adults.

Objective: To assess whether the role of selenium on pre-diabetes is differential by age, given comorbidities and decreased β-cell function in older adults.

Research design and methods: We evaluated the cross-sectional association of blood selenium with the homeostatic model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β) in middle-aged (Aragon Workers Health Study [AWHS], N = 1186), and older (Seniors ENRICA [Study on Nutrition and Cardiovascular Risk in Spain]-2 [SEN-2], N = 915) diabetes-free adults. A subsample of participants from AWHS (N = 571) and SEN-2 (N = 603) had glucose and insulin repeated measurements for longitudinal analysis. We validated the cross-sectional dose-response associations in the 2011-2018 National Health and Nutrition Examination Survey (NHANES, N = 1317 middle age and N = 960 older) participants. Selenium was measured in whole blood with ICP-MS in AWHS, SEN-2 and NHANES.

Results: The cross-sectional geometric mean ratios (95% confidence intervals) per two-fold selenium increase were 1.09 (1.01, 1.19) for HOMA-IR and 1.15 (1.06, 1.24) for HOMA-β in AWHS; and 1.13 (0.98, 1.31) and 1.03 (0.90, 1.18), in SEN-2. The cross-sectional dose-response associations were consistent in NHANES, with mostly increasingly positive trends for both HOMA endpoints in younger adults and a plateau at levels >~150 μg/L in older adults. The longitudinal dose-response consistently showed positive associations at high selenium dose for both HOMA endpoints in the younger, but not the older, study population.

Conclusions: Increased blood selenium was associated with increased insulin resistance and β-cell function in middle-aged, but not in older individuals, especially for β-cell function. The results suggest that selenium-associated insulin resistance might induce compensatory increased β-cell function at younger ages, being this compensatory capacity decreased with aging.

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来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
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