{"title":"中草药漱口水和苄胺漱口水预防头颈癌患者放射性口腔黏膜炎的疗效比较：系统评价和网络荟萃分析。","authors":"Rahul Mohandas, Subhashree Mohapatra","doi":"10.1038/s41432-025-01117-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Benzydamine mouthwash is beneficial in avoiding radiation-induced oral mucositis (RIOM) in patients with head and neck cancer, but it is also expensive and has negative side effects, while herbal mouthwashes offer a potential, easily accessible alternative with less side effects and bioactive characteristics. Hence, the aim of the systematic review and network meta-analysis was to assess and compare the efficacy of herbal mouthwash and benzydamine mouthwash in preventing RIOM among head and neck cancer patients.</p><p><strong>Methods: </strong>After searching Scopus, PubMed, Cochrane, Science Direct, EBSCO Host, Lilacs, Science Direct, Web of Science, and Google Scholar from the earliest available year till July 15, 2024, 79 articles were obtained. Four full-text publications met the eligibility requirements and underwent additional processing for data extraction. PICO Strategy: P: Head and neck cancer patients, I: Herbal mouthwash, C: Benzydamine mouthwash, O: Reduction in radiation-induced oral mucositis. The review only comprised randomised controlled trials. The risk of bias assessment and quality of evidence were assessed using the RoB-2 Tool and GRADE Tool respectively.</p><p><strong>Results: </strong>Curcumin mouthwash was most effective in reducing the incidence of oral mucositis followed by sumac-rose and turmeric mouthwash. Curcumin, turmeric, and sumac-rose mouthwashes were found to be effective in delaying the onset of oral mucositis as compared to the benzydamine group. Turmeric mouthwash followed by curcumin and sumac-rose mouthwash were found to be more effective in reducing the severity of oral mucositis.</p><p><strong>Conclusion: </strong>The current review concludes that curcumin, turmeric, and sumac-rose mouthwashes are more effective than benzydamine mouthwash in preventing RIOM. These natural alternatives show promising results for improving patient outcomes and should be investigated further to be used clinically.</p><p><strong>Prospero registration number: </strong>CRD42024570913.</p>","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative evaluation of the efficacy of herbal and benzydamine mouthwashes in preventing radiation-induced oral mucositis among head and neck cancer patients: a systematic review and network meta-analysis.\",\"authors\":\"Rahul Mohandas, Subhashree Mohapatra\",\"doi\":\"10.1038/s41432-025-01117-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Benzydamine mouthwash is beneficial in avoiding radiation-induced oral mucositis (RIOM) in patients with head and neck cancer, but it is also expensive and has negative side effects, while herbal mouthwashes offer a potential, easily accessible alternative with less side effects and bioactive characteristics. 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引用次数: 0
摘要
背景：苯胺漱口水有助于避免头颈癌患者的放射性口腔黏膜炎（RIOM），但它也很昂贵并且有副作用，而草药漱口水提供了一个潜在的，容易获得的替代品，副作用更小，生物活性更强。因此，本系统评价和网络荟萃分析的目的是评估和比较草药漱口水和苄胺漱口水在预防头颈癌患者RIOM的疗效。方法：检索Scopus、PubMed、Cochrane、Science Direct、EBSCO Host、Lilacs、Science Direct、Web of Science、谷歌Scholar等最早可查年份至2024年7月15日的论文79篇。四份全文出版物符合资格要求，并进行了额外的数据提取处理。PICO策略：P：头颈癌患者，I：草药漱口水，C：苄胺漱口水，O：减少放射性口腔黏膜炎。该综述仅包括随机对照试验。分别使用rob2工具和GRADE工具评估偏倚风险和证据质量。结果：姜黄素漱口水对降低口腔黏膜炎的发生率最有效，其次为紫苏玫瑰漱口水和姜黄漱口水。与苯胺组相比，姜黄素、姜黄和漆树玫瑰漱口水在延缓口腔黏膜炎发作方面被发现有效。姜黄漱口水，其次是姜黄素漱口水和漆树玫瑰漱口水，在减轻口腔黏膜炎的严重程度方面更有效。结论：姜黄素、姜黄、漆树玫瑰漱口水对RIOM的预防效果优于苄胺漱口水。这些天然替代品在改善患者预后方面显示出有希望的结果，应进一步研究以用于临床。普洛斯彼罗注册号：CRD42024570913。
Comparative evaluation of the efficacy of herbal and benzydamine mouthwashes in preventing radiation-induced oral mucositis among head and neck cancer patients: a systematic review and network meta-analysis.
Background: Benzydamine mouthwash is beneficial in avoiding radiation-induced oral mucositis (RIOM) in patients with head and neck cancer, but it is also expensive and has negative side effects, while herbal mouthwashes offer a potential, easily accessible alternative with less side effects and bioactive characteristics. Hence, the aim of the systematic review and network meta-analysis was to assess and compare the efficacy of herbal mouthwash and benzydamine mouthwash in preventing RIOM among head and neck cancer patients.
Methods: After searching Scopus, PubMed, Cochrane, Science Direct, EBSCO Host, Lilacs, Science Direct, Web of Science, and Google Scholar from the earliest available year till July 15, 2024, 79 articles were obtained. Four full-text publications met the eligibility requirements and underwent additional processing for data extraction. PICO Strategy: P: Head and neck cancer patients, I: Herbal mouthwash, C: Benzydamine mouthwash, O: Reduction in radiation-induced oral mucositis. The review only comprised randomised controlled trials. The risk of bias assessment and quality of evidence were assessed using the RoB-2 Tool and GRADE Tool respectively.
Results: Curcumin mouthwash was most effective in reducing the incidence of oral mucositis followed by sumac-rose and turmeric mouthwash. Curcumin, turmeric, and sumac-rose mouthwashes were found to be effective in delaying the onset of oral mucositis as compared to the benzydamine group. Turmeric mouthwash followed by curcumin and sumac-rose mouthwash were found to be more effective in reducing the severity of oral mucositis.
Conclusion: The current review concludes that curcumin, turmeric, and sumac-rose mouthwashes are more effective than benzydamine mouthwash in preventing RIOM. These natural alternatives show promising results for improving patient outcomes and should be investigated further to be used clinically.
期刊介绍：
Evidence-Based Dentistry delivers the best available evidence on the latest developments in oral health. We evaluate the evidence and provide guidance concerning the value of the author''s conclusions. We keep dentistry up to date with new approaches, exploring a wide range of the latest developments through an accessible expert commentary. Original papers and relevant publications are condensed into digestible summaries, drawing attention to the current methods and findings. We are a central resource for the most cutting edge and relevant issues concerning the evidence-based approach in dentistry today. Evidence-Based Dentistry is published by Springer Nature on behalf of the British Dental Association.
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