依多沙班致急性间质性肾炎。

IF 1 Q4 UROLOGY & NEPHROLOGY
Shiko Gen, Ririko Higashi, Natsuki Nagae, Ryuta Kigure, Yuta Kamikubo, Kanako Nobe, Naofumi Ikeda
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引用次数: 0

摘要

76岁男性,无特殊病史,被诊断为房颤,开始服用依多沙班。开始使用依多沙班7天后,观察到肾功能不全。患者在开始使用依多沙班后发生急性肾损伤,怀疑有抗凝剂相关性肾病,在发病第5天行肾活检以证实诊断。肾活检结果显示肾小管内未见红细胞铸型,间质内见淋巴细胞和浆细胞浸润炎性细胞,诊断为急性间质性肾炎。没有发现提示自身免疫性疾病,药物诱导的依多沙班淋巴细胞刺激试验阳性,导致诊断为依多沙班诱导的急性间质性肾炎。除了抗凝相关肾病外,药物性间质性肾炎也应被认为是抗凝药物开始使用后急性肾损伤的原因之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Edoxaban-induced acute interstitial nephritis.

A 76 year-old man with no specific medical history was diagnosed with atrial fibrillation and was started on edoxaban. Seven days after starting edoxaban, renal dysfunction was observed. He was suspected of having anticoagulant-related nephropathy due to acute kidney injury that occurred after starting edoxaban, and a renal biopsy was performed on day 5 of the illness to confirm the diagnosis. The renal biopsy results showed no red blood cell casts in the renal tubules, and inflammatory cell infiltration of lymphocytes and plasma cells was found in the interstitium, leading to a diagnosis of acute interstitial nephritis. There were no findings suggestive of autoimmune disease, and a drug-induced lymphocyte stimulation test to edoxaban was positive, leading to a diagnosis of edoxaban-induced acute interstitial nephritis. In addition to anticoagulant-related nephropathy, drug-induced interstitial nephritis should be considered as a cause of acute kidney injury after initiation of anticoagulant drugs.

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来源期刊
CEN Case Reports
CEN Case Reports UROLOGY & NEPHROLOGY-
CiteScore
1.90
自引率
0.00%
发文量
80
期刊介绍: Clinical and Experimental Nephrology (CEN) Case Reports is a peer-reviewed online-only journal, officially published biannually by the Japanese Society of Nephrology (JSN).  The journal publishes original case reports in nephrology and related areas.  The purpose of CEN Case Reports is to provide clinicians and researchers with a forum in which to disseminate their personal experience to a wide readership and to review interesting cases encountered by colleagues all over the world, from whom contributions are welcomed.
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