α2-肾上腺素能受体刺激对If阻断大鼠离体心肌梗死的影响。

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI:10.1007/s10517-025-06324-y

N I Ziyatdinova, A M Kuptsova, L I Faskhutdinov, R R Shakirov, T L Zefirov

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引用次数: 0

摘要

我们研究了If阻断后α - 2肾上腺素受体刺激对实验性心肌梗死急性期langendorff离体大鼠心脏功能的影响。在ZD7288 （10-9 M）阻断If的背景下，可乐定（10-6 M）刺激α2-肾上腺素受体，可降低假手术大鼠和急性心肌梗死动物左心室心肌收缩力、HR、冠状动脉血流量和左心室收缩持续时间。假手术大鼠和急性心肌梗死动物经初步If阻断（10-9 M）后α2-肾上腺素受体刺激的舒张和收缩周期持续时间增加。ZD7288在10-5 M浓度下刺激肾上腺受体，两组左室压、HR、冠状动脉血流量和左室心肌收缩持续时间均降低。假手术大鼠和急性心肌梗死动物在If阻断（10-5 M）背景下α2-肾上腺素受体刺激时舒张和收缩周期持续时间增加。

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The Effect of α₂-Adrenergic Receptor Stimulation on the Isolated Hearts from Rats with Acute Myocardial Infarction against the Background of I_f Blockade.

We studied the effect of α₂-adrenoreceptor stimulation after preliminary I_f blockade on the function of the Langendorff-isolated rat heart in the acute stage of experimental myocardial infarction. Stimulation of α₂-adrenoreceptors with clonidine (10^-6 M) against the background of I_f blockade with ZD7288 (10^-9 M) reduced the contractility of the left ventricular myocardium, HR, coronary blood flow, and the duration of the left ventricular myocardium contraction in sham-operated rats and animals with acute myocardial infarction. The duration of relaxation and contraction cycle during α₂-adrenoreceptor stimulation after preliminary I_f blockade (10^-9 M) was increased in sham-operated rats and in animals with acute myocardial infarction. Stimulation of adrenoreceptors against the background of application of ZD7288 in a concentration of 10^-5 M decreased the left ventricular pressure, HR, coronary blood flow, and the duration of left ventricular myocardial contraction in both groups. The duration of the relaxation and contraction cycle during α₂-adrenoreceptor stimulation against the background of I_f blockade (10^-5 M) increased in sham-operated rats and animals with acute myocardial infarction.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.