运动限制对大鼠铜含量的影响。

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI:10.1007/s10517-025-06326-w

R I Zaripova, G G Yafarova, V V Andrianov, M I Sungatullina, N I Ziyatdinova, Kh L Gainutdinov, T L Zefirov

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引用次数: 0

摘要

从第21天开始运动活动受限的大鼠，通过分析心脏和肝脏组织中含铜顺磁复合物的水平，用电子顺磁共振（EPR）谱法评估铜含量。通过Cu2+-二乙基二硫代氨基甲酸盐配合物（Cu2+-(DETC)2）的特征EPR信号强度来评估铜含量。结果发现，限制运动30天后，心脏和肝脏组织中铜含量分别增加了2.2倍和2.9倍。

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Effect of Motor Activity Restriction on Copper Content in Rats.

In rats subjected to increasing restriction of motor activity starting from day 21 days of life, copper content was evaluated by electron paramagnetic resonance (EPR) spectroscopy by analyzing the levels of copper-containing paramagnetic complexes in the heart and liver tissues. Copper content was assessed by the intensity of the characteristic EPR signal from the Cu²⁺-diethyldithiocarbamate complex (Cu²⁺-(DETC)₂). It was found that after restriction of motor activity for 30 days, copper content in the heart and liver tissues increased by 2.2 and 2.9 times, respectively.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.