Junaid Shafi Banday, Sajjad Ahmed, Qazi Naveed Ahmed
{"title":"Copper(I)-catalyzed coupling of alkynyl glycosides: synthesis of buta-1,3-diyne-linked disaccharides and dinucleosides.","authors":"Junaid Shafi Banday, Sajjad Ahmed, Qazi Naveed Ahmed","doi":"10.1039/d4ob01872a","DOIUrl":null,"url":null,"abstract":"<p><p>Herein we report copper-catalyzed coupling of alkynyl glycosides facilitating the synthesis of buta-1,3-diyne-linked disaccharides. The reaction is characterized by mild conditions employing eco-friendly reagents, resulting in good yields of the desired products. This methodology exhibits significant functional group tolerance with broad substrate scope. Furthermore, we have successfully extended this approach to the synthesis of buta-1,3-diyne-linked dinucleosides.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4ob01872a","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Copper(I)-catalyzed coupling of alkynyl glycosides: synthesis of buta-1,3-diyne-linked disaccharides and dinucleosides.
Herein we report copper-catalyzed coupling of alkynyl glycosides facilitating the synthesis of buta-1,3-diyne-linked disaccharides. The reaction is characterized by mild conditions employing eco-friendly reagents, resulting in good yields of the desired products. This methodology exhibits significant functional group tolerance with broad substrate scope. Furthermore, we have successfully extended this approach to the synthesis of buta-1,3-diyne-linked dinucleosides.
期刊介绍:
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.