孤独症谱系障碍和功能性便秘患儿胃造口管置入。

JPGN reports Pub Date : 2024-11-07 eCollection Date: 2025-02-01 DOI:10.1002/jpr3.12138
Shruthi Srinivas, Ihab Halaweish, Kristine L Griffin, Cameron Rodriguez, Liese C C Pruitt, Kevin G Stephenson, Lina Yossef, Richard J Wood, Kent C Williams
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引用次数: 0

摘要

目的:患有功能性便秘(FC)和自闭症谱系障碍(ASD)的儿童通常面临感觉和行为状况,无法给予口服药物治疗来改善便秘和尿失禁。我们的目的是评估有口服药物困难的ASD和FC儿童是否可以从胃造口管(GT)放置中获益。方法:对2020年至2023年诊断为ASD和FC的儿童进行单机构回顾性分析。如果儿童患有便秘,对日常功能有不利影响,并且拒绝适当的口服药物治疗,则被认为是GT的候选者。在GT放置前和GT放置后收集ASD严重程度和FC症状的数据。结果:9例患者行GT放置术。中位年龄为7.4岁(四分位数间距[IQR]: 4.8-9.7)。在进行ASD评估的5人中,有4人智商极低,适应能力极低;九个孩子中只有一个会说话。放置GT前,大多数患者有布里斯托尔1或2黏性大便(66.7%);放置后,大多数患者有布里斯托尔5或6黏稠度大便(66.7%)。7名儿童在GT前排便紧张;术后仅1例患儿紧张,无管移位或部位感染。便秘组(+38.5,IQR: 27.5-54.3)和给药组(+31.5,IQR: 0.0-75.0)胃肠道生活质量评分均有改善。结论:GT放置可能是FC和ASD儿童的可行选择,并发症最少,便秘改善,生活质量改善。进一步的前瞻性研究将确保这些结果的普遍性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gastrostomy tube placement for children with autism spectrum disorders and functional constipation.

Objectives: Children with functional constipation (FC) and autism spectrum disorder (ASD) often face sensory and behavioral conditions that prevent giving oral medical therapy to improve constipation and incontinence. We aimed to assess whether children with ASD and FC who had difficulty in taking oral medications could benefit from gastrostomy tube (GT) placement.

Methods: A single-institution retrospective review was performed in children diagnosed with ASD and FC from 2020 to 2023. Children were considered candidates for GT if they suffered from constipation that adversely affected daily function and refused adequate oral medical therapy. Data were collected on ASD severity and FC symptoms before GT and after GT placement.

Results: There were nine patients who underwent GT placement. Median age was 7.4 years (interquartile range [IQR]: 4.8-9.7). Of the five with available ASD evaluations, four had extremely low intelligence quotient and extremely low adaptive skills; only one child of the nine was verbal. Before GT placement, most patients had Bristol 1 or 2 consistency stool (66.7%); following placement, most had Bristol 5 or 6 consistency stool (66.7%). Seven children strained with bowel movements before GT; only one child strained after GT. There were no tube dislodgements or site infections. Gastrointestinal quality of life scores improved for both constipation (+38.5, IQR: 27.5-54.3) and medication administration (+31.5, IQR: 0.0-75.0).

Conclusions: GT placement may be a viable option in children with FC and ASD with minimal complications, improvement in constipation, and improvement in quality of life. Further prospective study will ensure generalizability of these results.

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