粪便菌群移植根除幽门螺杆菌感染:临床实践与理论假设。

eGastroenterology Pub Date : 2024-12-23 eCollection Date: 2024-10-01 DOI:10.1136/egastro-2024-100099
Zhi-Ning Ye, Guy D Eslick, Shao-Gang Huang, Xing-Xiang He
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引用次数: 0

摘要

抗生素耐药性的持续增加导致以抗生素为基础的根除方案对幽门螺杆菌(H. pylori)感染的根除率呈下降趋势。服用单一的益生菌对根除幽门螺杆菌感染的效果有限。这篇综述表明,粪便微生物群移植(FMT)作为一种新的治疗方法,无论是作为单一治疗还是辅助治疗,在根除幽门螺杆菌感染和预防不良事件方面都显示出有益的效果。FMT在根除幽门螺杆菌中的作用可能与粪便悬浮液中的一些治疗成分直接或间接相关,包括细菌、病毒、抗菌肽和代谢物。此外,供体选择、粪便悬浮液制备和递送方法的差异被认为是决定FMT治疗幽门螺杆菌感染有效性的主要因素。未来的研究应完善FMT的操作流程,以达到治疗幽门螺杆菌感染的最佳效果,并探索FMT对幽门螺杆菌的作用机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Faecal microbiota transplantation for eradicating Helicobacter pylori infection: clinical practice and theoretical postulation.

The sustained increase in antibiotic resistance leads to a declining trend in the eradication rate of Helicobacter pylori (H. pylori) infection with antibiotic-based eradication regimens. Administration of a single probiotic shows limited efficacy in eradicating H. pylori infection. This review indicates that faecal microbiota transplantation (FMT), a novel therapeutic approach, either as a monotherapy or adjunctive therapy, exhibits beneficial effects in terms of the eradication of H. pylori infection and the prevention of adverse events. The role of FMT in H. pylori eradication may be associated directly or indirectly with some therapeutic constituents within the faecal suspension, including bacteria, viruses, antimicrobial peptides and metabolites. In addition, variations in donor selection, faecal suspension preparation and delivery methods are believed to be the main factors determining the effectiveness of FMT for the treatment of H. pylori infection. Future research should refine the operational procedures of FMT to achieve optimal efficacy for H. pylori infection and explore the mechanisms by which FMT acts against H. pylori.

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