Early signs of long-term pain: prospective network profiles from late adolescence and lifelong follow-up.

This study applies network theory to registry data to identify prospective differences between individuals who develop long-term pain later in life and those who do not. The research is based on assessments of biological, psychological, and social variables in late adolescence during military conscription in Sweden. The analysis reveals significant differences in the network profiles of adolescent men who later developed long-term pain. These differences are reflected in several network-based outputs, including global, nodal, and edge levels, revealing a consistent picture of the pain-associated network profile. This profile demonstrates how those vulnerable to long-term pain have a specific configuration of variables that skew away from the rest of the population, mainly relating to psychosocial aspects.