为细胞周期调节的闭锁机制建模的概念框架。

IF 1.9 4区数学 Q2 BIOLOGY

Mathematical Biosciences Pub Date : 2025-02-10 DOI:10.1016/j.mbs.2025.109396

Punit Gandhi , Yangyang Wang

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引用次数: 0

摘要

两个具有相互抑制的相同的范德波尔振荡器被认为是一个概念框架，用于模拟细胞周期调节的锁存机制。特别是，振子偏向于闭锁状态，其中存在全局吸引的稳态平衡，没有耦合。抑制耦合诱导稳定的大振幅交替振荡，模拟正常细胞周期。发现模型内的同斜分支负责从正常细胞周期过渡到内周期，其中两个振荡子中只有一个经历大幅度振荡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A conceptual framework for modeling a latching mechanism for cell cycle regulation

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A conceptual framework for modeling a latching mechanism for cell cycle regulation

Two identical van der Pol oscillators with mutual inhibition are considered as a conceptual framework for modeling a latching mechanism for cell cycle regulation. In particular, the oscillators are biased to a latched state in which there is a globally attracting steady-state equilibrium without coupling. The inhibitory coupling induces stable alternating large-amplitude oscillations that model the normal cell cycle. A homoclinic bifurcation within the model is found to be responsible for the transition from normal cell cycling to endocycles in which only one of the two oscillators undergoes large-amplitude oscillations.

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来源期刊

Mathematical Biosciences 生物-生物学

CiteScore

7.50

自引率

2.30%

发文量

审稿时长

18 days

期刊介绍： Mathematical Biosciences publishes work providing new concepts or new understanding of biological systems using mathematical models, or methodological articles likely to find application to multiple biological systems. Papers are expected to present a major research finding of broad significance for the biological sciences, or mathematical biology. Mathematical Biosciences welcomes original research articles, letters, reviews and perspectives.