[18F-PSMA-1007 PET/CT联合血清前列腺总特异性抗原预测国际泌尿病理学会前列腺癌病理分级的临床价值]。

Q3 Medicine
Y F Bo, R R Tian, L L Bao, M Zhao, J Zhou, H Li, H L Hao, E W Xu
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Univariate and multivariate logistic regressions were used to identify the independent influencing factors for ISUP pathological grading of prostate cancer. The receiver operating characteristic (ROC) curves were used to predict the efficacy between the high and low ISUP grades for prostate cancer. <b>Results:</b> Of the 117 patients, 20 were in ISUP Group 1, 25 in Group 2, 18 in Group 3, 32 in Group 4, and 22 in Group 5. Of these, 63 were in the low-grade group (Groups 1-3) and 54 were in the high-grade group (Groups 4-5). The tumor long diameter was 3.10 (2.05, 4.25) cm, the prostate volume was 40.11 (33.13, 51.85) cm<sup>3</sup>, the serum tPSA was 19.71 (12.25, 42.83) ng/ml, the prostate specific antigen density (PSAD) was 0.51 (0.31, 1.01) ng·ml<sup>-1</sup>·cm<sup>-3</sup>, the maximum standard uptake value of the lesion (SUVmax) was 15.24 (10.87, 22.03), and the tumor/spleen uptake ratio (TSR) was 1.61 (1.08, 2.15) in the 117 patients. The correlation analysis displayed that the SUVmax, TSR, and tPSA were positively correlated with ISUP groups (<i>r</i>=0.640, 0.619, and 0.500, <i>P</i><0.01). The differences among SUVmax, TSR, long diameter, tPSA, and PSAD were statistically significant when compared among the five ISUP groups (<i>H=</i>48.98, 45.63, 26.82, 33.95, and 23.81, <i>P</i><0.001). The differencesin serum tPSA (<i>z</i>=5.19), PSAD (<i>z</i>=4.64), long diameter (<i>z</i>=3.19), SUVmax (<i>z</i>=5.57), and TSR (<i>z</i>=5.53) of the patients between the low-grade group and the high-grade group were statistically significant (<i>P</i><0.01). In multivariate analysis, TSR (<i>OR</i>=4.172, 95% <i>CI</i>: 2.095-8.308, <i>P</i><0.001) and the serum tPSA (<i>OR</i>=1.042, 95% <i>CI</i>: 1.014-1.070, <i>P</i><0.01) were independent influencing factors for ISUP grades. ROC analysis revealed that the area under the curve for the <sup>18</sup>F-PSMA-1007 PET/CT parameters SUVmax and TSR to predict low- or high-grade ISUP for prostate cancer was 0.800 (95% <i>CI</i>: 0.717-0.883) and 0.797 (95% <i>CI</i>: 0.713-0.881), respectively. Among the 70 patients who underwent radical prostatectomy, the postoperative recurrence rate of high-grade ISUP patients was higher than that of low-grade patients (54.8% and 25.6%, <i>χ<sup>2</sup></i>=6.21, <i>P</i><0.05). <b>Conclusions:</b> <sup>18</sup>F-PSMA-1007 PET/CT has good application in predicting ISUP grading of prostate cancer. TSR and the serum tPSA are independent predictors for the pathological grade.</p>","PeriodicalId":39868,"journal":{"name":"中华肿瘤杂志","volume":"47 2","pages":"175-182"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Clinical value of <sup>18</sup>F-PSMA-1007 PET/CT combined with serum total prostate specific antigen in predicting International Society of Urological Pathology pathological grading of prostate cancer].\",\"authors\":\"Y F Bo, R R Tian, L L Bao, M Zhao, J Zhou, H Li, H L Hao, E W Xu\",\"doi\":\"10.3760/cma.j.cn112152-20240417-00156\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Objective:</b> To discuss the correlation of International Society of Urological Pathology (ISUP) pathological grading with<sup>18</sup>F-prostate specific membrane antigen (PSMA)-1007 positron emission tomography-computed tomography (PET/CT) parameters and serum total prostate specific antigen (tPSA) in prostate cancer, and assess the clinical value of PET/CT combined with tPSA in predicting the ISUP pathological grade of prostate cancer. <b>Methods:</b> The correlation of ISUP pathological grade with primary parameters of PET/CT images and serum tPSA of 117 patients diagnosed with prostate cancer at Shanxi Cancer Hospital from August 2018 to February 2023 and taken <sup>18</sup>F-PSMA-1007 PET/CT imaging were retrospectively analyzed. 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引用次数: 0

摘要

目的:探讨国际泌尿病理学会(ISUP)病理分级与前列腺癌18f -前列腺特异性膜抗原(PSMA)-1007正电子发射断层扫描-计算机断层扫描(PET/CT)参数及血清前列腺总特异性抗原(tPSA)的相关性,评价PET/CT联合tPSA预测前列腺癌ISUP病理分级的临床价值。方法:回顾性分析山西省肿瘤医院2018年8月至2023年2月117例确诊前列腺癌患者的PET/CT影像主要参数及血清tPSA与ISUP病理分级的相关性。采用单因素和多因素logistic回归来确定ISUP对前列腺癌病理分级的独立影响因素。采用受试者工作特征(ROC)曲线预测高、低ISUP分级对前列腺癌的疗效。结果117例患者中,ISUP 1组20例,2组25例,3组18例,4组32例,5组22例。其中低分级组63例(1 ~ 3组),高分级组54例(4 ~ 5组)。117例患者肿瘤长径为3.10 (2.05,4.25)cm,前列腺体积40.11 (33.13,51.85)cm3,血清tPSA为19.71 (12.25,42.83)ng/ml,前列腺特异性抗原密度(PSAD)为0.51 (0.31,1.01)ng·ml-1·cm-3,病变最大标准摄取值(SUVmax)为15.24(10.87,22.03),肿瘤/脾脏摄取比(TSR)为1.61(1.08,2.15)。相关性分析显示,SUVmax、TSR、tPSA与ISUP组呈正相关(r=0.640、0.619、0.500,P<0.01)。5个ISUP组间SUVmax、TSR、长径、tPSA、PSAD的差异均有统计学意义(H=48.98、45.63、26.82、33.95、23.81,P<0.001)。低分级组与高分级组患者血清tPSA (z=5.19)、PSAD (z=4.64)、长径(z=3.19)、SUVmax (z=5.57)、TSR (z=5.53)差异均有统计学意义(P<0.01)。在多因素分析中,TSR (OR=4.172, 95% CI: 2.095 ~ 8.308, P<0.001)和血清tPSA (OR=1.042, 95% CI: 1.014 ~ 1.070, P<0.01)是ISUP分级的独立影响因素。ROC分析显示,18F-PSMA-1007 PET/CT参数SUVmax和TSR预测前列腺癌低级别或高级别ISUP的曲线下面积分别为0.800 (95% CI: 0.717-0.883)和0.797 (95% CI: 0.713-0.881)。70例根治性前列腺切除术患者中,高级别ISUP患者术后复发率高于低级别患者(54.8%、25.6%,χ2=6.21, P<0.05)。结论:18F-PSMA-1007 PET/CT在预测前列腺癌ISUP分级中具有较好的应用价值。TSR和血清tPSA是病理分级的独立预测因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Clinical value of 18F-PSMA-1007 PET/CT combined with serum total prostate specific antigen in predicting International Society of Urological Pathology pathological grading of prostate cancer].

Objective: To discuss the correlation of International Society of Urological Pathology (ISUP) pathological grading with18F-prostate specific membrane antigen (PSMA)-1007 positron emission tomography-computed tomography (PET/CT) parameters and serum total prostate specific antigen (tPSA) in prostate cancer, and assess the clinical value of PET/CT combined with tPSA in predicting the ISUP pathological grade of prostate cancer. Methods: The correlation of ISUP pathological grade with primary parameters of PET/CT images and serum tPSA of 117 patients diagnosed with prostate cancer at Shanxi Cancer Hospital from August 2018 to February 2023 and taken 18F-PSMA-1007 PET/CT imaging were retrospectively analyzed. Univariate and multivariate logistic regressions were used to identify the independent influencing factors for ISUP pathological grading of prostate cancer. The receiver operating characteristic (ROC) curves were used to predict the efficacy between the high and low ISUP grades for prostate cancer. Results: Of the 117 patients, 20 were in ISUP Group 1, 25 in Group 2, 18 in Group 3, 32 in Group 4, and 22 in Group 5. Of these, 63 were in the low-grade group (Groups 1-3) and 54 were in the high-grade group (Groups 4-5). The tumor long diameter was 3.10 (2.05, 4.25) cm, the prostate volume was 40.11 (33.13, 51.85) cm3, the serum tPSA was 19.71 (12.25, 42.83) ng/ml, the prostate specific antigen density (PSAD) was 0.51 (0.31, 1.01) ng·ml-1·cm-3, the maximum standard uptake value of the lesion (SUVmax) was 15.24 (10.87, 22.03), and the tumor/spleen uptake ratio (TSR) was 1.61 (1.08, 2.15) in the 117 patients. The correlation analysis displayed that the SUVmax, TSR, and tPSA were positively correlated with ISUP groups (r=0.640, 0.619, and 0.500, P<0.01). The differences among SUVmax, TSR, long diameter, tPSA, and PSAD were statistically significant when compared among the five ISUP groups (H=48.98, 45.63, 26.82, 33.95, and 23.81, P<0.001). The differencesin serum tPSA (z=5.19), PSAD (z=4.64), long diameter (z=3.19), SUVmax (z=5.57), and TSR (z=5.53) of the patients between the low-grade group and the high-grade group were statistically significant (P<0.01). In multivariate analysis, TSR (OR=4.172, 95% CI: 2.095-8.308, P<0.001) and the serum tPSA (OR=1.042, 95% CI: 1.014-1.070, P<0.01) were independent influencing factors for ISUP grades. ROC analysis revealed that the area under the curve for the 18F-PSMA-1007 PET/CT parameters SUVmax and TSR to predict low- or high-grade ISUP for prostate cancer was 0.800 (95% CI: 0.717-0.883) and 0.797 (95% CI: 0.713-0.881), respectively. Among the 70 patients who underwent radical prostatectomy, the postoperative recurrence rate of high-grade ISUP patients was higher than that of low-grade patients (54.8% and 25.6%, χ2=6.21, P<0.05). Conclusions: 18F-PSMA-1007 PET/CT has good application in predicting ISUP grading of prostate cancer. TSR and the serum tPSA are independent predictors for the pathological grade.

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中华肿瘤杂志
中华肿瘤杂志 Medicine-Medicine (all)
CiteScore
1.40
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