可见光介导的四氢异喹啉类和异吲哚类无需外加光催化剂的有氧α-氧化反应

IF 4.2 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules Pub Date : 2025-02-06 DOI:10.3390/molecules30030743

Taiqiang Ye, Yuzheng Li, Feng Zhao, Aorou Song, Zhaoxia Zhong, Shenpeng Tan, Feng Li

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Visible-Light-Mediated Aerobic α-Oxygenation of Tetrahydroisoquinolines and Isoindolines Without External Photocatalysts.

A visible-light-mediated strategy for the direct oxygenation of N-substituted tetrahydroisoquinolines and isoindolines to the corresponding benzo-fused lactams under clean conditions without using any external photocatalysts has been developed. The reaction was performed in the presence of a catalytic amount of base and oxygen. Mechanistic studies reveal that the reaction is initiated by the substrates themselves as photosensitizers. Additionally, BHT could be used as a buffer-like additive to improve reaction selectivity and product yield in this photo-oxidation process.

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.