氯氮平的作用机制。

IF 4.5 3区医学 Q1 CLINICAL NEUROLOGY

Journal of Psychopharmacology Pub Date : 2025-04-01 Epub Date: 2025-02-13 DOI:10.1177/02698811251319458

Paul D Morrison, Sameer Jauhar, Allan H Young

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引用次数: 0

摘要

先前关于氯氮平优于其他抗精神病药物的假设未能经受住时间的考验。在这里，我们描述了氯氮平在周围神经系统的独特药理学如何为解决氯氮平在中枢神经系统的谜题提供线索。氯氮平似乎是一类新的抗精神病药物的原型，现在进入临床精神病学，它能激活毒蕈碱乙酰胆碱受体。

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The mechanism of action of clozapine.

Previous hypotheses for the superiority of clozapine over other antipsychotics have failed to stand the test of time. Here we describe how the unique pharmacology of clozapine in the peripheral nervous system held clues for solving the puzzle of clozapine in the central nervous system. Clozapine appears to have been the prototype for a new class of antipsychotics, now entering clinical psychiatry, which activates muscarinic acetylcholine receptors.

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来源期刊

Journal of Psychopharmacology 医学-精神病学

CiteScore

8.60

自引率

4.90%

发文量

126

审稿时长

3-8 weeks

期刊介绍： The Journal of Psychopharmacology is a fully peer-reviewed, international journal that publishes original research and review articles on preclinical and clinical aspects of psychopharmacology. The journal provides an essential forum for researchers and practicing clinicians on the effects of drugs on animal and human behavior, and the mechanisms underlying these effects. The Journal of Psychopharmacology is truly international in scope and readership.