{"title":"有组织的跑步机训练作为减轻前列腺肿瘤小鼠肿瘤生长和保持脂肪组织和肌肉力量的策略。","authors":"Arthur Dieumegard, Suzanne Dufresne, Cindy Richard, Luz Orfila, Brice Martin, Laurent Rouvière, Arsênio Rodrigues Oliveira, Mikaël Croyal, Romain Mathieu, Amélie Rébillard","doi":"10.1249/MSS.0000000000003675","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Exercise is widely recognized for providing numerous benefits to prostate cancer (PCa) survivors. Numerous preclinical studies have investigated the role of exercise on tumor progression, but results are often controversial, largely due to variations in experimental protocols.</p><p><strong>Methods: </strong>In this study, the comprehensive effects of exercise on PCa were evaluated with two different aerobic exercises, forced and structured exercise training (ET) on treadmill, and voluntary wheel running (VWR). Human PCa PPC-1 cells or PBS was injected into athymic nude mice, randomized into four groups: healthy, cancer control (CaCTL), cancer with exercise training (CaET), and cancer with voluntary wheel running (CaVWR).</p><p><strong>Results: </strong>ET significantly reduced tumor growth (290.38 ± 75.43 mm 3 ) compared with CaCTL mice (374.84 ± 86.15 mm 3 , P = 0.0227). ET also regulated plasma IL-6 concentration, protected against cancer-induced adipose tissue loss (CaCTL = 171.21 ± 86.73 mg, CaET = 341.71 ± 137.24 mg; P = 0.0295) and preserved strength (CaCTL = 126.53 ± 6.68 g, CaET = 137.32 ± 6.39 g; P = 0.0018). However, ET did not protect against cancer-induced muscle mass loss (CaCTL = 175.06 ± 18.07 mg, CaET = 181.41 ± 14.59 mg). In contrast, VWR did not provide similar benefits on the assessed cancer-related outcomes, aside from preserving muscle strength (CaCTL = 126.53 ± 6.68 g, CaVWR = 134.59 ± 7.01 g; P = 0.0204).</p><p><strong>Conclusions: </strong>ET represented an effective strategy against PCa by limiting tumor growth, but also by mitigating inflammation and adipose tissue loss and preserving muscle strength, whereas VWR only provided limited benefits. The exercise parameters are emerging as a critical factor in combating PCa, warranting further investigation.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1452-1462"},"PeriodicalIF":3.9000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Structured Treadmill Training as a Strategy to Mitigate Tumor Growth and Preserve Adipose Tissue and Muscle Strength in Prostate Tumor-Bearing Mice.\",\"authors\":\"Arthur Dieumegard, Suzanne Dufresne, Cindy Richard, Luz Orfila, Brice Martin, Laurent Rouvière, Arsênio Rodrigues Oliveira, Mikaël Croyal, Romain Mathieu, Amélie Rébillard\",\"doi\":\"10.1249/MSS.0000000000003675\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Exercise is widely recognized for providing numerous benefits to prostate cancer (PCa) survivors. Numerous preclinical studies have investigated the role of exercise on tumor progression, but results are often controversial, largely due to variations in experimental protocols.</p><p><strong>Methods: </strong>In this study, the comprehensive effects of exercise on PCa were evaluated with two different aerobic exercises, forced and structured exercise training (ET) on treadmill, and voluntary wheel running (VWR). Human PCa PPC-1 cells or PBS was injected into athymic nude mice, randomized into four groups: healthy, cancer control (CaCTL), cancer with exercise training (CaET), and cancer with voluntary wheel running (CaVWR).</p><p><strong>Results: </strong>ET significantly reduced tumor growth (290.38 ± 75.43 mm 3 ) compared with CaCTL mice (374.84 ± 86.15 mm 3 , P = 0.0227). ET also regulated plasma IL-6 concentration, protected against cancer-induced adipose tissue loss (CaCTL = 171.21 ± 86.73 mg, CaET = 341.71 ± 137.24 mg; P = 0.0295) and preserved strength (CaCTL = 126.53 ± 6.68 g, CaET = 137.32 ± 6.39 g; P = 0.0018). However, ET did not protect against cancer-induced muscle mass loss (CaCTL = 175.06 ± 18.07 mg, CaET = 181.41 ± 14.59 mg). In contrast, VWR did not provide similar benefits on the assessed cancer-related outcomes, aside from preserving muscle strength (CaCTL = 126.53 ± 6.68 g, CaVWR = 134.59 ± 7.01 g; P = 0.0204).</p><p><strong>Conclusions: </strong>ET represented an effective strategy against PCa by limiting tumor growth, but also by mitigating inflammation and adipose tissue loss and preserving muscle strength, whereas VWR only provided limited benefits. The exercise parameters are emerging as a critical factor in combating PCa, warranting further investigation.</p>\",\"PeriodicalId\":18426,\"journal\":{\"name\":\"Medicine and Science in Sports and Exercise\",\"volume\":\" \",\"pages\":\"1452-1462\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicine and Science in Sports and Exercise\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1249/MSS.0000000000003675\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"SPORT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine and Science in Sports and Exercise","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1249/MSS.0000000000003675","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/13 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"SPORT SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
目的:运动被广泛认为对前列腺癌(PCa)幸存者有许多好处。许多临床前研究已经调查了运动对肿瘤进展的作用,但结果往往存在争议,主要是由于实验方案的差异。方法:在本研究中,通过两种不同的有氧运动,在跑步机上强迫和结构化的运动训练(ET)和自愿轮式跑步(VWR),评估运动对前列腺癌的综合影响。将人PCa PPC-1细胞或PBS注射到胸腺裸小鼠体内,随机分为四组:健康组、癌症对照组(CaCTL)、癌症运动训练组(CaET)和癌症自愿轮式跑步组(CaVWR)。结果:与CaCTL小鼠(374.84±86.15 mm3, p = 0.0227)相比,ET显著降低肿瘤生长(290.38±75.43 mm3)。ET还能调节血浆IL-6浓度,防止癌症诱导的脂肪组织损失(CaCTL = 171.21±86.73 mg;Ca ET = 341.71±137.24 mg, p = 0.0295),保存强度(CaCTL = 126.53±6.68 g;CaET = 137.32±6.39 g, p = 0.0018)。然而,ET对癌症引起的肌肉质量损失没有保护作用(CaCTL = 175.06±18.07 mg;CaET = 181.41±14.59 mg)。相比之下,除了保持肌肉力量外,VWR在评估的癌症相关结果上没有提供类似的益处(CaCTL = 126.53±6.68 g;CaVWR = 134.59±7.01 g, p = 0.0204)。结论:ET通过限制肿瘤生长,减轻炎症和脂肪组织损失,保持肌肉力量,是对抗PCa的有效策略,而VWR仅提供有限的益处。运动参数正在成为对抗前列腺癌的一个关键因素,值得进一步研究。
Structured Treadmill Training as a Strategy to Mitigate Tumor Growth and Preserve Adipose Tissue and Muscle Strength in Prostate Tumor-Bearing Mice.
Purpose: Exercise is widely recognized for providing numerous benefits to prostate cancer (PCa) survivors. Numerous preclinical studies have investigated the role of exercise on tumor progression, but results are often controversial, largely due to variations in experimental protocols.
Methods: In this study, the comprehensive effects of exercise on PCa were evaluated with two different aerobic exercises, forced and structured exercise training (ET) on treadmill, and voluntary wheel running (VWR). Human PCa PPC-1 cells or PBS was injected into athymic nude mice, randomized into four groups: healthy, cancer control (CaCTL), cancer with exercise training (CaET), and cancer with voluntary wheel running (CaVWR).
Results: ET significantly reduced tumor growth (290.38 ± 75.43 mm 3 ) compared with CaCTL mice (374.84 ± 86.15 mm 3 , P = 0.0227). ET also regulated plasma IL-6 concentration, protected against cancer-induced adipose tissue loss (CaCTL = 171.21 ± 86.73 mg, CaET = 341.71 ± 137.24 mg; P = 0.0295) and preserved strength (CaCTL = 126.53 ± 6.68 g, CaET = 137.32 ± 6.39 g; P = 0.0018). However, ET did not protect against cancer-induced muscle mass loss (CaCTL = 175.06 ± 18.07 mg, CaET = 181.41 ± 14.59 mg). In contrast, VWR did not provide similar benefits on the assessed cancer-related outcomes, aside from preserving muscle strength (CaCTL = 126.53 ± 6.68 g, CaVWR = 134.59 ± 7.01 g; P = 0.0204).
Conclusions: ET represented an effective strategy against PCa by limiting tumor growth, but also by mitigating inflammation and adipose tissue loss and preserving muscle strength, whereas VWR only provided limited benefits. The exercise parameters are emerging as a critical factor in combating PCa, warranting further investigation.
期刊介绍:
Medicine & Science in Sports & Exercise® features original investigations, clinical studies, and comprehensive reviews on current topics in sports medicine and exercise science. With this leading multidisciplinary journal, exercise physiologists, physiatrists, physical therapists, team physicians, and athletic trainers get a vital exchange of information from basic and applied science, medicine, education, and allied health fields.