早发性胃肠道癌症和代谢危险因素：来自2021年全球疾病负担研究的全球趋势

IF 6.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings Pub Date : 2025-07-01 DOI:10.1016/j.mayocp.2024.10.021

Pojsakorn Danpanichkul MD , Kanokphong Suparan MD , Thanida Auttapracha , Primrose Tothanarungroj , Siwanart Kongarin , Krittameth Rakwong , Darren Jun Hao Tan MBBS , Banthoon Sukphutanan MD , Mark D. Muthiah MBBS , Daniel Tung MD , Junpeng Luo MD , Asahiro Morishita MD , En Ying Tan MD , Hirokazu Takahashi MD , Omar Y. Mousa MD , Rashid N. Lui MBBS , Mazen Noureddin MD , Donghee Kim MD , Denise M. Harnois DO , Ju Dong Yang MD , Karn Wijarnpreecha MD

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引用次数: 0

摘要

目的：探讨年轻患者胃肠道（GI）癌发病率的上升趋势及其相关危险因素。患者和方法：我们使用来自2021年全球疾病负担研究的数据来评估早发性（15至49岁）胃肠道癌症的发病率、死亡率和残疾调整生命年（DALYs），包括糖尿病和高体重指数导致的死亡率和DALYs。结果：2021年，早发性胃肠道癌症约有499,800例病例，285,900例死亡，1401万DALYs。早发性胃肠道肿瘤占总发病率的9.51%，占总死亡率的7.73%。从2000年到2021年，早发性结直肠癌的年龄标准化发病率增加(年变化百分比，0.84%；95% CI， 0.71%至0.97%)和胆道癌(年变化百分比，0.19%；95% CI， 0.06%至0.32%)。2021年，有20,860人死于代谢风险因素导致的早发性胃肠道癌症。在所有类型的早发性GI癌症中，代谢危险因素导致的早发性GI癌症的年龄标准化死亡率均有所增加。结论：我们的研究强调了早发性胃肠道癌症的显著增加，强调了需要一个包括控制危险因素，特别是代谢危险因素，采用有效的筛查方法和有效的癌症管理的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Early-Onset Gastrointestinal Cancers and Metabolic Risk Factors: Global Trends From the Global Burden of Disease Study 2021

查看原文本刊更多论文

Early-Onset Gastrointestinal Cancers and Metabolic Risk Factors: Global Trends From the Global Burden of Disease Study 2021

Objective

To explore the increasing incidence of gastrointestinal (GI) cancers and related risk factors in younger patients.

Patient and Methods

We used data from the Global Burden of Disease Study 2021 to assess the incidence, mortality, and disability-adjusted life years (DALYs) for early-onset (age 15 to 49 years) GI cancers, including mortality and DALYs from diabetes mellitus and high body mass index.

Results

In 2021, there were approximately 499,800 incident cases, 285,900 deaths, and 14.01 million DALYs from early-onset GI cancer. Early-onset GI cancer accounted for 9.51% of the incidence and 7.73% of the mortality of the overall GI cancer. From 2000 to 2021, age-standardized incidence rates increased for early-onset colorectal cancer (annual percent change, 0.84%; 95% CI, 0.71% to 0.97%) and biliary tract cancer (annual percent change, 0.19%; 95% CI, 0.06% to 0.32%). In 2021, there were 20,860 deaths from early-onset GI cancer attributable to metabolic risk factors. The age-standardized death rates of early-onset GI cancer from metabolic risk factors increased in all types of early-onset GI cancer.

Conclusion

Our research highlights a significant increase in early-onset GI cancer, emphasizing the need for a strategy that includes controlling risk factors, particularly metabolic risk factors, adoption of effective screening methods, and effective cancer management.

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来源期刊

Mayo Clinic proceedings 医学-医学：内科

CiteScore

16.80

自引率

1.10%

发文量

383

审稿时长

37 days

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