过早心室复合体负担与心肌病风险：一项横断面研究。

IF 8 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC. Clinical electrophysiology Pub Date : 2025-05-01 DOI:10.1016/j.jacep.2025.01.004

Sarah Slaven MD , Lohit Garg MD , Rafay Sabzwari MD , Christopher Barrett MD , Alexis Tumolo MD , Lukasz Cerbin MD , Amneet Sandhu MD , Matthew Zipse MD , Wendy Tzou MD , Michael Rosenberg MD

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引用次数: 0

摘要

背景：一些观察性研究已经描述了室性早搏复合物（早搏）和心室功能之间的关系，这些研究表明，较高的室性早搏负荷在降低左心室射血分数（LVEF）中起着致病作用。然而，迄今为止，很少有研究在人群水平上检查室性早搏和心肌病的关系。目的：在这个治疗不可知的横断面研究中，我们检查了PVC负担与LVEF下降的关系。方法：我们对2017年4月22日至2023年2月20日期间获得的bb30万例患者动态监护仪进行了分析。受试者监测≥24小时，PVC负荷≥5%，监测后3个月内进行经胸超声心动图检查。结果：纳入样本共1451例患者，年龄68.2±14.5岁，女性占39.6%。平均PVC负担率为12.4±7.4%（5% ~ 43.4%）。在746例经胸超声心动图患者中，平均LVEF为55.6%±9.2%(25%-76.8%)，其中171例患者（22.9%）存在LVEF。结论：总之，我们没有发现证据表明单独的PVC负担是心肌病的独立预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Burden of Premature Ventricular Complexes and Risk of Cardiomyopathy

Background

The association between premature ventricular complexes (PVCs) and ventricular function has been described in several observational studies, where it has been implied that a higher burden of PVCs plays a causative role in reducing left ventricular ejection fraction (LVEF). To date, however, few studies have examined the association of PVCs and cardiomyopathy on a population level.

Objectives

In this treatment-agnostic, cross-sectional study, the authors examined the association of PVC burden with depressed LVEF.

Methods

We performed an analysis of >30,000 ambulatory monitors obtained on patients from April 22, 2017, and February 20, 2023. Subjects with ≥24 hours of monitoring, a PVC burden of ≥5%, and a transthoracic echocardiogram performed within 3 months of monitoring were included. The presence of cardiomyopathy was defined as LVEF <50%. Clinical factors including comorbidities and relevant medications were included and adjusted for.

Results

The included sample included a total of 1,451 patients, with age 68.2 ± 14.5 years, female sex in 39.6%. The average PVC burden was 12.4% ± 7.4% (5%-43.4%). Of 746 subjects with a transthoracic echocardiogram, the mean LVEF was 55.6% ± 9.2% (25%-76.8%), with 171 subjects (22.9%) having an LVEF <50%. In both unadjusted and adjusted analyses, we found no significant association between percentage of PVCs and LVEF (P = 0.78), nor with PVC burden and depressed left ventricular function (P = 0.13).

Conclusions

We found no evidence that the PVC burden alone is an independent predictor of cardiomyopathy.

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来源期刊

JACC. Clinical electrophysiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

10.30

自引率

5.70%

发文量

250

期刊介绍： JACC: Clinical Electrophysiology is one of a family of specialist journals launched by the renowned Journal of the American College of Cardiology (JACC). It encompasses all aspects of the epidemiology, pathogenesis, diagnosis and treatment of cardiac arrhythmias. Submissions of original research and state-of-the-art reviews from cardiology, cardiovascular surgery, neurology, outcomes research, and related fields are encouraged. Experimental and preclinical work that directly relates to diagnostic or therapeutic interventions are also encouraged. In general, case reports will not be considered for publication.