[DDAH1蛋白：生物学功能，在癌变过程中的作用]。

Q4 Medicine

Arkhiv patologii Pub Date : 2025-01-01 DOI:10.17116/patol20258701160

E A Prosekina, V A Shapkina, A E Karpov, E Yu Fedorutseva, A S Artemyeva

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引用次数: 0

摘要

二甲基精氨酸二甲基氨基水解酶1 （Dimethylaminohydrolase 1, DDAH1）是一种能够降解内源性一氧化氮合酶抑制剂——不对称二甲基精氨酸的必需酶。DDAH1表达的增加和随后NO生成的增加与癌变有关。特别是，DDAH1参与肿瘤细胞形成血管网络，血管源性拟态，这与肿瘤进展和患者预后不良密切相关。这就是为什么DDAH1可能成为治疗癌症的潜在治疗靶点的原因。

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[DDAH1 protein: biological functions, role in carcinogenesis processes].

Dimethylarginine Dimethylaminohydrolase 1 (DDAH1) is an essential enzyme capable of degrading asymmetric dimethylarginine, which is an endogenous inhibitor of nitric oxide synthase. Increased expression of DDAH1 and subsequent increased NO production are associated with carcinogenesis. In particular, DDAH1 is involved in the creation of a vascular network by tumor cells, vasculogenic mimicry, which is closely associated with tumor progression and poor patient prognosis. This is the reason why DDAH1 may be a potential therapeutic target for the treatment of cancer.

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来源期刊

Arkhiv patologii Medicine-Pathology and Forensic Medicine

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The journal deals with original investigations on pressing problems of general pathology and pathologic anatomy, newest research methods, major issues of the theory and practice as well as problems of experimental, comparative and geographic pathology. To inform readers latest achievements of Russian and foreign medicine the journal regularly publishes editorial and survey articles, reviews of the most interesting Russian and foreign books on pathologic anatomy, new data on modern methods of investigation (histochemistry, electron microscopy, autoradiography, etc.), about problems of teaching, articles on the history of pathological anatomy development both in Russia and abroad.