印度班加罗尔夏前季节环境PM2.5中多环芳烃、其衍生物和邻苯二甲酸酯的同时测定及其对蛋白质聚集性疾病的潜在影响

IF 5.8 3区环境科学与生态学 0 ENVIRONMENTAL SCIENCES

Environmental Science and Pollution Research Pub Date : 2025-02-13 DOI:10.1007/s11356-025-36035-w

Durga Prasad Patnana, Sai Phalguna Kanikaram, Piyush Kumar, Vijay Sai Krishna Cheerala, Venketesh Sivaramakrishnan, Prashant Tripathi, Boggarapu Praphulla Chandra

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引用次数: 0

摘要

与颗粒物（PM）有关的空气污染是世界上大多数大都市的一个主要问题。吸入接触有机物质，如多环芳烃（PAHs）， PAHs的衍生物（含氧和硝化PAHs），以及与PM结合的邻苯二甲酸酯（PAEs），由于其致癌，致突变和内分泌干扰的性质，是主要关注的问题。本研究首次采用优化的高效液相色谱-串联质谱联用（HPLC-MS/MS）方法，报道了包括多环芳烃、多环芳烃衍生物和多环芳烃在内的22种芳香有机物质。此外，该优化方法用于测量在印度大城市班加罗尔收集的22种与环境细颗粒物（PM2.5）结合的目标有机成分，这是夏前季节试点研究的一部分。在所报道的化合物中，苯并[b]荧光蒽（3.82 ng m-3）、9-硝基蒽（10.47 ng m-3）和邻苯二甲酸二乙酯（5.38 ng m-3）是含量最多的多环芳烃，它们分别是多环芳烃的衍生物和PAEs。确定的多环芳烃诊断比率表明，采样地点主要受交通排放的影响。在抽样期间，1类致癌物苯并[a]芘偶尔超过印度国家环境空气质量标准（NAAQs）规定的限值。此外，我们使用表达交互反应DNA结合蛋白43 （TDP43）的肌萎缩性侧索硬化症（ALS）酵母模型进行了初步研究，结果表明，与PM2.5结合的多环芳烃（PAHs）和PAEs等常见有机物诱导野生型TDP43的聚集显著升高。本研究的初步结果表明，有必要进一步详细评估吸入接触与班加罗尔环境PM结合的有机成分所造成的健康风险。

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Simultaneous determination of polycyclic aromatic hydrocarbons, their derivatives, and phthalic acid esters bound to ambient PM2.5 during pre-summer season in Bengaluru, India, and potential effect on protein aggregation diseases

Air pollution pertaining to particulate matter (PM) is a major issue in most of the metropolitan cities across the world. Inhalation exposure to organic species like polycyclic aromatic hydrocarbons (PAHs), derivatives of PAHs (oxygenated and nitrated PAHs), and phthalic acid esters (PAEs) bound to PM is of major concern owing to its carcinogenic, mutagenic, and endocrine disrupting nature. In this study for the first time, we report a total of 22 aromatic organic species which include PAHs, derivatives of PAHs, and PAEs using an optimized high-performance liquid chromatography coupled to the tandem mass spectrometer (HPLC–MS/MS) method. Further, this optimized method was used to carry out the measurements of the 22 targeted organic constituents bound to the ambient fine particulate matter (PM_2.5) collected in Bengaluru, a metropolitan city in India as a part of a pilot study during the pre-summer season. Among the reported compounds, benzo[b]fluoranthene (3.82 ng m⁻³), 9-nitroanthracene (10.47 ng m⁻³), and diethyl phthalate (5.38 ng m⁻³) are the most abundant PAHs, the derivatives of PAHs, and PAEs, respectively. Determined diagnostic ratios of PAHs have shown that the sampling site is majorly influenced by traffic emissions. Benzo[a]pyrene, a Group 1 carcinogen has occasionally exceeded the limits set by National Ambient Air Quality Standards (NAAQs), India during the sampling period. Further, a preliminary study was performed using a yeast model of amyotrophic lateral sclerosis (ALS) expressing transactive response DNA binding protein 43 (TDP43) and we demonstrated that commonly reported organics such as PAHs and PAEs bound to PM_2.5 have induced significantly elevated aggregation in wild type TDP43. Preliminary results of this study indicate that there is a need for further detailed health risk assessment due to inhalation exposure of organic constituents bound to the ambient PM in Bengaluru.

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来源期刊

Environmental Science and Pollution Research 环境科学-环境科学

CiteScore

8.70

自引率

17.20%

发文量

6549

审稿时长

3.8 months

期刊介绍： Environmental Science and Pollution Research (ESPR) serves the international community in all areas of Environmental Science and related subjects with emphasis on chemical compounds. This includes: - Terrestrial Biology and Ecology - Aquatic Biology and Ecology - Atmospheric Chemistry - Environmental Microbiology/Biobased Energy Sources - Phytoremediation and Ecosystem Restoration - Environmental Analyses and Monitoring - Assessment of Risks and Interactions of Pollutants in the Environment - Conservation Biology and Sustainable Agriculture - Impact of Chemicals/Pollutants on Human and Animal Health It reports from a broad interdisciplinary outlook.