聚乳酸-羟基乙酸包封白桦酸纳米载体的研制及抗肿瘤效果评价

IF 4.2 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Macromolecular Materials and Engineering Pub Date : 2025-02-14 DOI:10.1002/mame.202570004

Cyril Tlou Selepe, Khanyisile Sheer Dhlamini, Lesego Tshweu, Lusisizwe Kwezi, Bathabile Ramalapa, Suprakas Sinha Ray

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引用次数: 0

摘要

封面：天然抗肿瘤药物因其对健康细胞的低细胞毒性而受到高度重视。然而，它们相对较短的系统半衰期和较低的生物利用度给临床应用带来了障碍。本研究介绍了一种克服这些障碍的策略，通过开发一种采用生物聚合物乳液技术的药物传递系统来优化天然抗肿瘤剂白桦酸的治疗效果。更多细节可以在Bathabile Ramalapa， Suprakas Sinha Ray及其同事的文章2400283中找到。Suprakas Sinha Ray与INMYWORK工作室的团队合作设计了封面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Development and Evaluation of Poly(Lactic-Co-Glycolic Acid) Encapsulated Betulinic Acid Nanocarrier for Improved Anti-Tumor Efficacy

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Development and Evaluation of Poly(Lactic-Co-Glycolic Acid) Encapsulated Betulinic Acid Nanocarrier for Improved Anti-Tumor Efficacy

Front Cover: Natural anti-tumor agents are highly regarded for their low cytotoxicity towards healthy cells. However, their relatively short systematic half-life and low bioavailability impose hurdles for clinical application. This study introduces a strategy to surmount these obstacles by developing a drug delivery system employing biopolymeric emulsion techniques to optimize the therapeutic efficacy of a natural anti-tumor agent, betulinic acid. More details can be found in article 2400283 by Bathabile Ramalapa, Suprakas Sinha Ray, and co-workers. Suprakas Sinha Ray designed the cover art in collaboration with the team at INMYWORK Studio.

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来源期刊

Macromolecular Materials and Engineering 工程技术-材料科学：综合

CiteScore

7.30

自引率

5.10%

发文量

328

审稿时长

1.6 months

期刊介绍： Macromolecular Materials and Engineering is the high-quality polymer science journal dedicated to the design, modification, characterization, processing and application of advanced polymeric materials, including membranes, sensors, sustainability, composites, fibers, foams, 3D printing, actuators as well as energy and electronic applications. Macromolecular Materials and Engineering is among the top journals publishing original research in polymer science. The journal presents strictly peer-reviewed Research Articles, Reviews, Perspectives and Comments. ISSN: 1438-7492 (print). 1439-2054 (online). Readership:Polymer scientists, chemists, physicists, materials scientists, engineers Abstracting and Indexing Information: CAS: Chemical Abstracts Service (ACS) CCR Database (Clarivate Analytics) Chemical Abstracts Service/SciFinder (ACS) Chemistry Server Reaction Center (Clarivate Analytics) ChemWeb (ChemIndustry.com) Chimica Database (Elsevier) COMPENDEX (Elsevier) Current Contents: Physical, Chemical & Earth Sciences (Clarivate Analytics) Directory of Open Access Journals (DOAJ) INSPEC (IET) Journal Citation Reports/Science Edition (Clarivate Analytics) Materials Science & Engineering Database (ProQuest) PASCAL Database (INIST/CNRS) Polymer Library (iSmithers RAPRA) Reaction Citation Index (Clarivate Analytics) Science Citation Index (Clarivate Analytics) Science Citation Index Expanded (Clarivate Analytics) SciTech Premium Collection (ProQuest) SCOPUS (Elsevier) Technology Collection (ProQuest) Web of Science (Clarivate Analytics)