一种新的交联方法用于胶原基皮肤模板的生物制造

IF 4.4 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Macromolecular bioscience Pub Date : 2025-02-14 DOI:10.1002/mabi.202570003

Weng Wan Chan, Keya Rani Roy, Bach Quang Le, Hariharan Ezhilarasu, Xiaoqian Zhang, Ryan Yi Da Lim, Avinanda Banerjee, Mariya Kuriakose, Krystle Joy Ng, Priya Murugan, Chun Ting Goh, Weibiao Zhou, May Win Naing, Srikala Raghavan, Deepak Choudhury

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引用次数: 0

摘要

封面：介绍了一种新的胶原蛋白海绵的紫外和戊二醛（UV/GA）交联工艺，与传统的脱热（DHT/GA）方法相比，交联时间从48小时缩短到24小时。胶原模板比商业产品更有效地支持人类真皮成纤维细胞增殖，并在小鼠模型中显示出可比的体内皮肤再生，为治疗三度烧伤提供了有希望的替代方案。更多细节可以在Srikala Raghavan， Deepak Choudhury及其同事的文章2400457中找到。用BioRender.com创建的图像。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A Novel Crosslinking Approach for Biomanufacturing of a Collagen-Based Skin Dermal Template

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A Novel Crosslinking Approach for Biomanufacturing of a Collagen-Based Skin Dermal Template

Front Cover: A novel ultraviolet and glutaraldehyde (UV/GA) crosslinking process for collagen sponges is introduced, reducing crosslinking time from 48 to 24 hours compared to conventional dehydrothermal (DHT/GA) methods. The collagen template supports human dermal fibroblast proliferation more effectively than commercial products and demonstrates comparable in vivo skin regeneration in mouse models, offering a promising alternative for treating third-degree burns. More details can be found in article 2400457 by Srikala Raghavan, Deepak Choudhury, and co-workers. Image created with BioRender.com.

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来源期刊

Macromolecular bioscience 生物-材料科学：生物材料

CiteScore

7.90

自引率

2.20%

发文量

211

审稿时长

1.5 months

期刊介绍： Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.