细胞器稳态需要escrt

IF 6 2区 生物学 Q1 CELL BIOLOGY
Tsan-Wen Lu, Adam Frost, Frank R. Moss III
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引用次数: 0

摘要

运输所需的内体分选复合物(ESCRT)催化整个细胞的膜形状转化。escrt的典型功能包括内体多泡体生物发生、包膜病毒出芽和子细胞膜脱落。ESCRT机制通常也是膜细胞器稳态所必需的,包括促进膜接触部位的脂质运输、修复膜损伤、驱动溶酶体分解代谢、维持核膜完整性等。在这里,我们回顾了最近发现的一部分,并强调了更好地理解ESCRT活动如何支持细胞健康的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Organelle homeostasis requires ESCRTs
The endosomal sorting complexes required for transport (ESCRT) catalyze membrane shape transformations throughout the cell. Canonical functions of the ESCRTs include endosomal multivesicular body biogenesis, enveloped virus budding, and abscission of daughter cell plasma membranes. The ESCRT machinery is also required for membranous organelle homeostasis generally, including by facilitating lipid transport at membrane contact sites, repairing membrane damage, driving lysosomal catabolism, and maintaining nuclear envelope integrity, among other roles. Here, we review a subset of recent discoveries and highlight opportunities to better understand how ESCRT activities support cell health.
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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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