人二尖瓣心内膜炎伴副氧弧菌血流感染致死1例，16S rDNA序列分析及文献复习

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-02-08 DOI:10.1016/j.diagmicrobio.2025.116739

Pierre Serandour , Chloé Plouzeau , Anthony Michaud , Lauranne Broutin , Julie Cremniter , Christophe Burucoa , Maxime Pichon

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引用次数: 0

摘要

微细菌种类是革兰氏阳性，非发酵，黄色色素棒，常见于动物和各种环境来源。本文报告的第一例致命的血液感染与二尖瓣心内膜炎引起的副氧化微杆菌在一个人的病人。方法64岁男性，除类风湿脊柱炎治疗外，无明显感染危险因素，出现严重胸痛、左腿麻痹、呼吸窘迫、高热。诊断调查显示缺血性中风和二尖瓣功能不全。尽管进行了瓣膜置换术和抗生素治疗，但患者病情恶化，导致瓣膜拔出、肺病和死亡。结果经16S rDNA基因测序鉴定为副氧双歧杆菌（M. paraoxydans）。结论本病例强调了利用测序技术准确鉴定微细菌种类的重要性。本报告强调需要进行研究和监测，以了解人类微细菌感染的临床特征、治疗策略和影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Lethal Case of Microbacterium paraoxydans Bloodstream Infection Associated with Mitral Endocarditis in Human: A Case Report, analyses of the 16S rDNA sequences and review of the literature

Introduction

Microbacterium species are gram-positive, non-fermentative, yellow-pigmented rods commonly found in animals and various environmental sources. Herein is reported the first case of a fatal bloodstream infection associated with mitral endocarditis caused by Microbacterium paraoxydans in a human patient.

Methods

A 64-year-old man without significant infectious risk factors, except for rheumatoid spondylarthritis treatment, developed severe chest pain, paralysis of the left leg, respiratory distress, and high fever. Diagnostic investigations revealed ischemic stroke and mitral insufficiency. Despite valve replacement surgery and antibiotic treatment, the patient's condition deteriorated, resulting in valve disinsertion, pneumopathy, and death.

Results

Blood cultures taken later confirmed the presence of Microbacterium sp., identified as M. paraoxydans by 16S rDNA gene sequencing.

Conclusion

This case highlights the importance of using sequencing for accurate identification of Microbacterium species. This report emphasizes the need for research and surveillance to understand the clinical characteristics, treatment strategies, and impact of Microbacterium infections in humans.

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.