Souvik Ray, Pritam Kumar Roy and N. D. Pradeep Singh*,
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Visible Light-Triggered Single-Component Photocage Nanoparticles for Combinatorial Photodynamic Therapy and Chemotherapy
Light-triggered chemo-PDT combinatorial therapy is an appealing strategy to advance therapeutic effectiveness and reduce cellular resistance. Herein, we are reporting visible light-activated single-component fluorescent organic nanoparticles (Acr-Cbl nano) based on a π-extended acridine photocage for the combinatorial treatment of chemotherapy and PDT. The high ROS (1O2) generation ability of Acr-Cbl nano, along with the delivery of the anticancer drug chlorambucil, exhibits a combinatorial effect in killing the cancer cells (LN18 glioblastoma) under visible light irradiation. In vitro studies demonstrate that Acr-Cbl nanocrystals can internalize inside the LN18 cells and show enhanced photocytotoxicity, leading to apoptotic cell death.
期刊介绍：
ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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