异吲哚酮与醇的电选择性和可控交叉偶联

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-01-30 DOI:10.1021/acs.joc.4c0283810.1021/acs.joc.4c02838

Mian Liu, Lingling Shi, Lianyou Zheng, Qiansong Gao*, Zhuoqi Zhang and Jinbao Xiang*,

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引用次数: 0

摘要

在温和的条件下，不需要金属催化剂和强碱，开发了一种新的、高效的异吲哚酮与等效醇的电选择性可控交叉偶联的电化学方法。该反应为3-烷氧基和n -羟甲基取代异吲哚酮的可控和有效合成提供了一种新的策略，该反应由4-OH-TEMPO调节，并耐受多种底物。该协议是构建具有高化学选择性的C-O和C-N键的有效工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Electroselective and Controlled Cross-Coupling of Isoindolinones with Alcohols

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Electroselective and Controlled Cross-Coupling of Isoindolinones with Alcohols

A novel and efficient electrochemical method for electroselective and controlled cross-coupling of isoindolinones with equivalent alcohols has been developed without the need for metal catalysts and strong bases under mild conditions. The reaction provides a novel strategy for the controllable and effective synthesis of 3-alkoxyl and N-hydroxymethyl-substituted isoindolinones, which is adjusted by 4-OH-TEMPO and tolerates various substrates. This protocol is an efficient tool for the construction of C–O and C–N bonds with high chemoselectivity.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.