三重G-C-T碱基编码自组装水溶性核碱基单体，具有广泛的生物材料和蛋白质生物偶联应用

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-02-12 DOI:10.1021/acs.joc.4c02745

Dharmendra Singh, Nilu V. Gone, Kiran Bandi, Disiya Davis, Kiran Sukumaran Nair, Gangadhar J. Sanjayan

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引用次数: 0

摘要

我们报道了自组装水溶性核碱基单体，具有广泛的生物材料和蛋白质生物偶联应用范围。这些核碱基单体具有天然的三重G-C-T核碱基，具有三个识别位点：DDA （G模拟物），DAA （C模拟物）和ADA （T模拟物）。使用易于获取的起始材料，这些单体可以以优异的收率合成，使其成为各种应用的良好选择。它们独特的结构特征，加上它们的水溶性，可能为创造新的生物材料提供令人兴奋的机会。

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Triple G-C-T Base-Coded Self-Assembling Water-Soluble Nucleobase Monomers with a Broad Scope for Biomaterial and Protein Bioconjugation Applications

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Triple G-C-T Base-Coded Self-Assembling Water-Soluble Nucleobase Monomers with a Broad Scope for Biomaterial and Protein Bioconjugation Applications

We report self-assembling water-soluble nucleobase monomers with a broad scope for biomaterial and protein bioconjugation applications. These nucleobase monomers are adorned with nature-inspired triple G-C-T nucleobases featuring three recognition sites: DDA (G mimic), DAA (C mimic), and ADA (T mimic). Using readily accessible starting materials, these monomers can be synthesized in excellent yields, making them good choices for diverse applications. Their unique structural features, coupled with their water solubility, may offer exciting opportunities for the creation of new biomaterials.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.