中胚层FN1形成心脏

IF 17.3 1区 生物学 Q1 CELL BIOLOGY
Daryl J. V. David
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引用次数: 0

摘要

心脏发育涉及组织力学、细胞极性、生长和细胞粘附,但它们在哺乳动物中正确形态发生的精确协调尚不清楚。Arriagada等人报道中胚层合成的细胞外基质(ECM)蛋白纤维连接蛋白(FN1)影响发育中的小鼠心脏背侧心包壁的多种细胞行为。作者使用Fn1flox/−;Mesp1Cre敲入小鼠有条件地去除中胚层中的FN1表达。Fn1中胚层突变体具有心脏功能和结构缺陷,提示中胚层Fn1在正常心脏形态发生中起作用。Fn1中胚层突变体破坏了心脏背侧心包壁的细胞形态,变得更圆、更少极化,并减少了YAP1/TAZ1核易位,表明机械反应途径被破坏。利用体外培养的小鼠胚胎成纤维细胞,作者发现FN1缺失的小鼠胚胎成纤维细胞可以在整合素受体与外源MnCl2激活后捆绑荧光标记的FN1。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mesoderm FN1 shaping the heart
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来源期刊
Nature Cell Biology
Nature Cell Biology 生物-细胞生物学
CiteScore
28.40
自引率
0.90%
发文量
219
审稿时长
3 months
期刊介绍: Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology
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