{"title":"天门冬氨酸转氨酶-血小板比值指数作为失代偿期肝硬化再代偿的预测指标。","authors":"Dedong Yin, Juanli Wu, Yuying Wang, Xu Liu","doi":"10.29271/jcpsp.2025.02.168","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationship between aspartate aminotransferase-to-platelet ratio index (APRI) level and recompensation in patients with hepatitis B-related decompensated cirrhosis.</p><p><strong>Study design: </strong>Analytical study. Place and Duration of the Study: The Second Hospital of Shandong University, Jian, China, and Weifang People's Hospital, China, from January 2016 to 2024.</p><p><strong>Methodology: </strong>A total of 166 patients with hepatitis B-related decompensated cirrhosis without antiviral treatment were included. All patients were observed for a minimum of 18 months. The main result is recompensation, defined as the latest Baveno VII restitution standard. The predictive value of the APRI was assessed by using the receiver operating characteristic (ROC) curves and logistics regression model.</p><p><strong>Results: </strong>In the group with baseline aspartate aminotransferase (AST) ≤40 U/L, APRI was identified as an independent predictor of recompensation in patients with hepatitis B-related decompensated cirrhosis (OR 0.04, 95% CI: 0.002 - 0.686, p = 0.026). For patients treated with nucleos(t)ide analogues (NAs), lower APRI was related to the higher rate of recompensation (OR 0.466, 95% CI: 0.291 - 0.747, p = 0.002). In the baseline AST ≤40 group and in the data one year after antiviral treatment, the AUROCs for APRI diagnosis of liver cirrhosis were 0.813 and 0.723, respectively.</p><p><strong>Conclusion: </strong>APRI may be used as an independent predictor of recompensation in patients with hepatitis B-related decompensated cirrhosis, particularly in patients undergoing NAs therapy and with low AST levels.</p><p><strong>Key words: </strong>Aspartate aminotransferase-to-platelet ratio index, Decompensated liver cirrhosis, Recompensation, Chronic hepatitis B.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 2","pages":"168-173"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aspartate Aminotransferase-to-Platelet Ratio Index as Predictors of Recompensation in Decompensated Cirrhosis.\",\"authors\":\"Dedong Yin, Juanli Wu, Yuying Wang, Xu Liu\",\"doi\":\"10.29271/jcpsp.2025.02.168\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To explore the relationship between aspartate aminotransferase-to-platelet ratio index (APRI) level and recompensation in patients with hepatitis B-related decompensated cirrhosis.</p><p><strong>Study design: </strong>Analytical study. Place and Duration of the Study: The Second Hospital of Shandong University, Jian, China, and Weifang People's Hospital, China, from January 2016 to 2024.</p><p><strong>Methodology: </strong>A total of 166 patients with hepatitis B-related decompensated cirrhosis without antiviral treatment were included. All patients were observed for a minimum of 18 months. The main result is recompensation, defined as the latest Baveno VII restitution standard. The predictive value of the APRI was assessed by using the receiver operating characteristic (ROC) curves and logistics regression model.</p><p><strong>Results: </strong>In the group with baseline aspartate aminotransferase (AST) ≤40 U/L, APRI was identified as an independent predictor of recompensation in patients with hepatitis B-related decompensated cirrhosis (OR 0.04, 95% CI: 0.002 - 0.686, p = 0.026). For patients treated with nucleos(t)ide analogues (NAs), lower APRI was related to the higher rate of recompensation (OR 0.466, 95% CI: 0.291 - 0.747, p = 0.002). In the baseline AST ≤40 group and in the data one year after antiviral treatment, the AUROCs for APRI diagnosis of liver cirrhosis were 0.813 and 0.723, respectively.</p><p><strong>Conclusion: </strong>APRI may be used as an independent predictor of recompensation in patients with hepatitis B-related decompensated cirrhosis, particularly in patients undergoing NAs therapy and with low AST levels.</p><p><strong>Key words: </strong>Aspartate aminotransferase-to-platelet ratio index, Decompensated liver cirrhosis, Recompensation, Chronic hepatitis B.</p>\",\"PeriodicalId\":94116,\"journal\":{\"name\":\"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP\",\"volume\":\"35 2\",\"pages\":\"168-173\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29271/jcpsp.2025.02.168\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29271/jcpsp.2025.02.168","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的:探讨乙型肝炎相关失代偿性肝硬化患者天门冬氨酸转氨酶血小板比值指数(APRI)水平与再代偿的关系。研究设计:分析性研究。研究地点和时间:2016年1月至2024年在山东大学附属第二医院和潍坊市人民医院进行。方法:共纳入166例未经抗病毒治疗的乙型肝炎相关失代偿性肝硬化患者。所有患者至少观察18个月。主要结果是补偿,定义为最新的巴维诺VII恢复标准。采用受试者工作特征(ROC)曲线和logistic回归模型评价APRI的预测价值。结果:在基线天冬氨酸转氨酶(AST)≤40 U/L的组中,APRI被确定为乙肝相关失代偿性肝硬化患者再代偿的独立预测因子(OR 0.04, 95% CI: 0.002 - 0.686, p = 0.026)。对于接受核苷类似物(NAs)治疗的患者,较低的APRI与较高的再代偿率相关(OR 0.466, 95% CI: 0.291 - 0.747, p = 0.002)。基线AST≤40组和抗病毒治疗后1年的数据中,APRI诊断肝硬化的auroc分别为0.813和0.723。结论:APRI可作为乙型肝炎相关失代偿性肝硬化患者再代偿的独立预测因子,特别是在接受NAs治疗和低AST水平的患者中。关键词:天冬氨酸转氨酶血小板比值指数失代偿性肝硬化代偿性慢性乙型肝炎
Aspartate Aminotransferase-to-Platelet Ratio Index as Predictors of Recompensation in Decompensated Cirrhosis.
Objective: To explore the relationship between aspartate aminotransferase-to-platelet ratio index (APRI) level and recompensation in patients with hepatitis B-related decompensated cirrhosis.
Study design: Analytical study. Place and Duration of the Study: The Second Hospital of Shandong University, Jian, China, and Weifang People's Hospital, China, from January 2016 to 2024.
Methodology: A total of 166 patients with hepatitis B-related decompensated cirrhosis without antiviral treatment were included. All patients were observed for a minimum of 18 months. The main result is recompensation, defined as the latest Baveno VII restitution standard. The predictive value of the APRI was assessed by using the receiver operating characteristic (ROC) curves and logistics regression model.
Results: In the group with baseline aspartate aminotransferase (AST) ≤40 U/L, APRI was identified as an independent predictor of recompensation in patients with hepatitis B-related decompensated cirrhosis (OR 0.04, 95% CI: 0.002 - 0.686, p = 0.026). For patients treated with nucleos(t)ide analogues (NAs), lower APRI was related to the higher rate of recompensation (OR 0.466, 95% CI: 0.291 - 0.747, p = 0.002). In the baseline AST ≤40 group and in the data one year after antiviral treatment, the AUROCs for APRI diagnosis of liver cirrhosis were 0.813 and 0.723, respectively.
Conclusion: APRI may be used as an independent predictor of recompensation in patients with hepatitis B-related decompensated cirrhosis, particularly in patients undergoing NAs therapy and with low AST levels.
Key words: Aspartate aminotransferase-to-platelet ratio index, Decompensated liver cirrhosis, Recompensation, Chronic hepatitis B.