儿科研究势在必行：通过了解新生儿临床药理学来解决药物开发中的新生儿问题。

Q2 Medicine

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-02-01 Epub Date: 2025-02-10 DOI:10.5863/1551-6776-30.1.8

An N Massaro, Elimika Pfuma Fletcher, Rajanikanth Madabushi, Gerri Baer, Dionna Green

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引用次数: 0

摘要

新生儿药物开发仍是卫生保健领域未满足的需求。虽然激励措施和立法授权对增加儿科患者的药物开发产生了一些影响，但新生儿治疗的进步面临着独特的挑战。本文综述了新生儿药物开发的相关监管历史、临床、药理学和伦理考虑。研究重点和未来的方向推进安全有效的药物，为脆弱的新生儿人口进行了讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Pediatric Research Imperative: Addressing Neonates in Drug Development Through Understanding Neonatal Clinical Pharmacology.

Drug development in the neonatal population remains an unmet need in health care. While incentives and legislative mandates have had some impact on increasing drug development in pediatric patients, the advancement of neonatal therapeutics faces unique challenges. This review summarizes relevant regulatory history, clinical, pharmacological and ethical considerations that characterize the landscape of drug development in neonates. Research priorities and future directions for advancing safe and effective medicines for the vulnerable neonatal population are discussed.

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来源期刊

Journal of Pediatric Pharmacology and Therapeutics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

2.40

自引率

0.00%

发文量

期刊介绍： The Journal of Pediatric Pharmacology and Therapeutics is the official journal of the Pediatric Pharmacy Advocacy Group. JPPT is a peer-reviewed multi disciplinary journal that is devoted to promoting the safe and effective use of medications in infants and children. To this end, the journal publishes practical information for all practitioners who provide care to pediatric patients. Each issue includes review articles, original clinical investigations, case reports, editorials, and other information relevant to pediatric medication therapy. The Journal focuses all work on issues related to the practice of pediatric pharmacology and therapeutics. The scope of content includes pharmacotherapy, extemporaneous compounding, dosing, methods of medication administration, medication error prevention, and legislative issues. The Journal will contain original research, review articles, short subjects, case reports, clinical investigations, editorials, and news from such organizations as the Pediatric Pharmacy Advocacy Group, the FDA, the American Academy of Pediatrics, the American Society of Health-System Pharmacists, and so on.