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通过体外进化预测疟原虫耐药性。

IF 7 1区 医学 Q1 PARASITOLOGY
Trends in parasitology Pub Date : 2025-03-01 Epub Date: 2025-02-10 DOI:10.1016/j.pt.2025.01.008
Liwang Cui
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引用次数: 0

摘要

关于化合物的耐药性和靶点的知识对抗疟疾药物的开发至关重要。Luth等通过对724个对118种化合物耐药的克隆进行体外进化和全基因组分析，系统分析了恶性疟原虫的抗性组，揭示了新的药物靶点、多药耐药位点和耐药的关键决定因素。
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Predicting Plasmodium drug resistance through in vitro evolution.

Knowledge about the resistibility and targets of compounds critically informs antimalarial drug development. Luth et al. systematically analyzed the resistome of Plasmodium falciparum through in vitro evolution and whole-genome analysis of 724 clones resistant to 118 compounds, revealing novel drug targets, multidrug resistance loci, and key determinants of resistance.

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来源期刊
Trends in parasitology
Trends in parasitology 医学-寄生虫学
CiteScore
14.00
自引率
3.10%
发文量
148
审稿时长
6-12 weeks
期刊介绍： Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.
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