Aaishah M Kaabi, Afrah F Alkhuriji, Zeneb A Babay, Ibrahim A Barakat, Abdullah M Kaabi, Reem M Kaabi
{"title":"因子I纤维蛋白原（rs6050）和因子XI血浆凝血活素（rs4253417）遗传多态性与沙特妇女复发性自然流产的关系","authors":"Aaishah M Kaabi, Afrah F Alkhuriji, Zeneb A Babay, Ibrahim A Barakat, Abdullah M Kaabi, Reem M Kaabi","doi":"10.15537/smj.2025.46.2.20240692","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To identify genetic polymorphisms in factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) in Saudi women with recurrent spontaneous miscarriage (RSM). Furthermore, to compare the levels of clotting factors in the blood of patients and healthy controls.</p><p><strong>Methods: </strong>The current study was conducted at the King Khalid University Hospital in Riyadh, Saudi Arabia, from September 2022 to June 2023. The study involved 100 Saudi women, 50 pregnant and 50 non-pregnant individuals, who experienced RSM. Furthermore, 100 healthy Saudi women, including 50 pregnant and 50 non-pregnant individuals, were also included as controls. TaqMan genotyping assays were used to determine single nucleotide polymorphisms in the promoter regions of the factor I and XI genes.</p><p><strong>Results: </strong>A significant correlation was found between the Factor I fibrinogen genotype (rs6050 C/T) and RSM in non-pregnant Saudi women. However, no significant correlation was observed between the Factor XI polymorphism (rs4253417 C/T) and RSM.</p><p><strong>Conclusion: </strong>We demonstrated a significant correlation between genetic polymorphisms in factor I fibrinogen in certain genes studied and RSM. This association could be attributed to changes in fibrinogen levels, which impact the coagulation process and lead to an increase in thrombotic events, which are recognized as risk factors for miscarriage. Notably, variations in the other genes examined did not exhibit any association with the risk of RSM.</p>","PeriodicalId":21453,"journal":{"name":"Saudi Medical Journal","volume":"46 2","pages":"150-156"},"PeriodicalIF":1.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822937/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) genetic polymorphisms and recurrent spontaneous miscarriage in Saudi women.\",\"authors\":\"Aaishah M Kaabi, Afrah F Alkhuriji, Zeneb A Babay, Ibrahim A Barakat, Abdullah M Kaabi, Reem M Kaabi\",\"doi\":\"10.15537/smj.2025.46.2.20240692\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To identify genetic polymorphisms in factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) in Saudi women with recurrent spontaneous miscarriage (RSM). Furthermore, to compare the levels of clotting factors in the blood of patients and healthy controls.</p><p><strong>Methods: </strong>The current study was conducted at the King Khalid University Hospital in Riyadh, Saudi Arabia, from September 2022 to June 2023. The study involved 100 Saudi women, 50 pregnant and 50 non-pregnant individuals, who experienced RSM. Furthermore, 100 healthy Saudi women, including 50 pregnant and 50 non-pregnant individuals, were also included as controls. TaqMan genotyping assays were used to determine single nucleotide polymorphisms in the promoter regions of the factor I and XI genes.</p><p><strong>Results: </strong>A significant correlation was found between the Factor I fibrinogen genotype (rs6050 C/T) and RSM in non-pregnant Saudi women. However, no significant correlation was observed between the Factor XI polymorphism (rs4253417 C/T) and RSM.</p><p><strong>Conclusion: </strong>We demonstrated a significant correlation between genetic polymorphisms in factor I fibrinogen in certain genes studied and RSM. This association could be attributed to changes in fibrinogen levels, which impact the coagulation process and lead to an increase in thrombotic events, which are recognized as risk factors for miscarriage. Notably, variations in the other genes examined did not exhibit any association with the risk of RSM.</p>\",\"PeriodicalId\":21453,\"journal\":{\"name\":\"Saudi Medical Journal\",\"volume\":\"46 2\",\"pages\":\"150-156\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822937/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Saudi Medical Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.15537/smj.2025.46.2.20240692\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Saudi Medical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.15537/smj.2025.46.2.20240692","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Association between factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) genetic polymorphisms and recurrent spontaneous miscarriage in Saudi women.
Objectives: To identify genetic polymorphisms in factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) in Saudi women with recurrent spontaneous miscarriage (RSM). Furthermore, to compare the levels of clotting factors in the blood of patients and healthy controls.
Methods: The current study was conducted at the King Khalid University Hospital in Riyadh, Saudi Arabia, from September 2022 to June 2023. The study involved 100 Saudi women, 50 pregnant and 50 non-pregnant individuals, who experienced RSM. Furthermore, 100 healthy Saudi women, including 50 pregnant and 50 non-pregnant individuals, were also included as controls. TaqMan genotyping assays were used to determine single nucleotide polymorphisms in the promoter regions of the factor I and XI genes.
Results: A significant correlation was found between the Factor I fibrinogen genotype (rs6050 C/T) and RSM in non-pregnant Saudi women. However, no significant correlation was observed between the Factor XI polymorphism (rs4253417 C/T) and RSM.
Conclusion: We demonstrated a significant correlation between genetic polymorphisms in factor I fibrinogen in certain genes studied and RSM. This association could be attributed to changes in fibrinogen levels, which impact the coagulation process and lead to an increase in thrombotic events, which are recognized as risk factors for miscarriage. Notably, variations in the other genes examined did not exhibit any association with the risk of RSM.
期刊介绍：
The Saudi Medical Journal is a monthly peer-reviewed medical journal. It is an open access journal, with content released under a Creative Commons attribution-noncommercial license.
The journal publishes original research articles, review articles, Systematic Reviews, Case Reports, Brief Communication, Brief Report, Clinical Note, Clinical Image, Editorials, Book Reviews, Correspondence, and Student Corner.
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