评价雷马唑仑在程序镇静中的作用。

IF 5.3 2区医学 Q1 NEUROSCIENCES

Current Neuropharmacology Pub Date : 2025-01-01 DOI:10.2174/011570159X367968250117034551

Genevieve Monanian, Brandon Yonel, Deborah Rupert, Alina Razak, Michelle DeLemos, Sergio D Bergese

{"title":"评价雷马唑仑在程序镇静中的作用。","authors":"Genevieve Monanian, Brandon Yonel, Deborah Rupert, Alina Razak, Michelle DeLemos, Sergio D Bergese","doi":"10.2174/011570159X367968250117034551","DOIUrl":null,"url":null,"abstract":"Remimazolam, a novel short-acting benzodiazepine, has garnered interest in the realm of procedural sedation. Targeting a desired level of sedation requires a medication with both anesthetic and analgesic properties, particularly in non-operating room anesthetizing locations. Via gammaaminobutyric acid type A receptor agonism, Remimazolam has demonstrated organ-independent metabolism and rapid time to both onset and recovery and has efficacy for procedural sedation in clinical trials. This article provides a review of the current literature on the utility of remimazolam for procedural sedation.","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":"1009-1020"},"PeriodicalIF":5.3000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272093/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evaluating Remimazolam for Procedural Sedation.\",\"authors\":\"Genevieve Monanian, Brandon Yonel, Deborah Rupert, Alina Razak, Michelle DeLemos, Sergio D Bergese\",\"doi\":\"10.2174/011570159X367968250117034551\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Remimazolam, a novel short-acting benzodiazepine, has garnered interest in the realm of procedural sedation. Targeting a desired level of sedation requires a medication with both anesthetic and analgesic properties, particularly in non-operating room anesthetizing locations. Via gammaaminobutyric acid type A receptor agonism, Remimazolam has demonstrated organ-independent metabolism and rapid time to both onset and recovery and has efficacy for procedural sedation in clinical trials. This article provides a review of the current literature on the utility of remimazolam for procedural sedation.\",\"PeriodicalId\":10905,\"journal\":{\"name\":\"Current Neuropharmacology\",\"volume\":\" \",\"pages\":\"1009-1020\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272093/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Neuropharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/011570159X367968250117034551\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Neuropharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/011570159X367968250117034551","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

雷马唑仑是一种新型短效苯二氮卓类药物，在程序性镇静领域引起了人们的兴趣。要达到理想的镇静水平，需要同时具有麻醉和镇痛特性的药物，特别是在非手术室麻醉部位。通过γ氨基丁酸A型受体激动作用，雷马唑仑在临床试验中表现出不依赖于器官的代谢和快速的起效和恢复时间，并具有程序性镇静作用。这篇文章提供了一个关于雷马唑仑的应用程序镇静目前的文献综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Evaluating Remimazolam for Procedural Sedation.

Remimazolam, a novel short-acting benzodiazepine, has garnered interest in the realm of procedural sedation. Targeting a desired level of sedation requires a medication with both anesthetic and analgesic properties, particularly in non-operating room anesthetizing locations. Via gammaaminobutyric acid type A receptor agonism, Remimazolam has demonstrated organ-independent metabolism and rapid time to both onset and recovery and has efficacy for procedural sedation in clinical trials. This article provides a review of the current literature on the utility of remimazolam for procedural sedation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Current Neuropharmacology 医学-神经科学

CiteScore

8.70

自引率

1.90%

发文量

369

审稿时长

>12 weeks

期刊介绍： Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.