使用基于剂量或基于效应的方法确定药物组合中的相互作用。

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Neuropharmacology Pub Date : 2025-02-06 DOI:10.2174/011570159X347472250130111339

Tinghe Yu, Tianyan Yu, Xinya Li, Min Li

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Determining the Interaction in a Drug Combination using the Dose-based or Effect-based Method.

The interaction in a drug combination can be assessed using either the method of Chou or Jin's method. The combination index in the former (i.e., CI-C) is calculated based on doses, while the latter (i.e., CI-J) is based on effects. This perspective demonstrates a correlation between 1/CI-C and CI-J when applied to both released and simulated data. Thus, 1/CI-C and CI-J are functionally equivalent for evaluating drug interaction. Combining these two indices is preferred; consistency shows a reliable verdict, and inconsistency indicates a requirement for further analyses. However, it has been observed that evaluating released data raises certain concerns.

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来源期刊

Current Neuropharmacology 医学-神经科学

CiteScore

8.70

自引率

1.90%

发文量

369

审稿时长

>12 weeks

期刊介绍： Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.