缺电子芳烃极性反转对取代的激进方法。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-01-23 DOI:10.1039/d4cc04914d

Shashank Singh , Arindam Kundu , Claire Empel , René Michael Koenigs , Ravi P. Singh

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引用次数: 0

摘要

我们开发了一种极性反转的缺电子芳烃对取代方案。为了实现广泛的底物所需的反应性和选择性，双管齐下的策略是必不可少的。此外，这种方法在芳烃的全氟烷基化中也显示出前景。控制实验和计算研究为观察到的选择性提供了机制上的见解。药物设计合成的潜力已经被这种经济和生态友好的方法所展示，这种方法提供了各种构建块的访问。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A radical approach towards polarity-reversed para-substitution of electron-deficient arenes†

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A radical approach towards polarity-reversed para-substitution of electron-deficient arenes†

We have developed a protocol for polarity-reversed para-substitution of electron-deficient arenes. In order to achieve desired reactivity and selectivity for a broad range of substrates, the dual pronged strategy is essential. Furthermore, this approach has also shown promise in perfluoroalkylation of arenes. Control experiments and computational studies provide a mechanistic insight for the observed selectivity. The potential for drug design synthesis has been showcased by this economical and ecofriendly method that provides access to a variety of building blocks.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.