丝素基水凝胶在抗菌领域的应用进展

IF 2.9 4区 化学 Q2 POLYMER SCIENCE
Pan Zou, Xiaoliang Li, Haiyun Zhao, Shenhong Qu, Zhichao Jiang, Xi Lei, Cimin Wu, Ling Liu
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引用次数: 0

摘要

丝素蛋白水凝胶以其良好的生物相容性、生物降解和保水性在伤口敷料和组织工程领域得到广泛应用。近几十年来,功能性sf基水凝胶的开发受到了医学界的广泛关注。多功能SF水凝胶是通过添加和组合具有促进细胞生长,抗菌,抗氧化和抗炎性能的治疗剂制备的。特别是,sf基水凝胶的抗菌活性在临床实践中至关重要。尽管人们对功能性丝蛋白水凝胶及其潜在的抗菌应用越来越感兴趣,但目前还缺乏对这一主题的全面综述。因此,本文旨在深入了解sf基水凝胶的抗菌应用进展情况,主要针对不同组分的负载情况进行综述。本文首先简要介绍了sf基水凝胶的制备方法。随后,综述了水凝胶中装载的各种成分,以期对抗菌领域有一个全面的认识。综述了抗菌药物在生物医学领域的应用,包括组织工程、药物缓释、伤口修复和黏合剂的应用。此外,还分析了开发基于sf的水凝胶所面临的挑战以及未来的前景。希望本研究能够促进顺丰材料在临床抗菌领域的应用与创新。©2024化学工业学会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent advances of silk-fibroin-based hydrogel in the field of antibacterial application

Recent advances of silk-fibroin-based hydrogel in the field of antibacterial application

Silk fibroin (SF) hydrogel has been popular in the wound dressing and tissue engineering fields for its good biocompatibility, biodegradation and water retention ability. The development of functional SF-based hydrogels has gained attention in recent decades in medical fields. Multifunctional SF hydrogel is prepared by the addition and combination of therapeutic agents with cell growth promoting, antibacterial, antioxidant and anti-inflammatory properties. In particular, the antibacterial activity of SF-based hydrogel is essential in clinical practice. Despite this growing interest in functional silk protein hydrogels and their potential antimicrobial applications, a comprehensive review on this topic is currently lacking. Therefore, this review aims to provide an in-depth understanding of the advanced status of the antibacterial application of SF-based hydrogel, mainly focused on different components loaded. The review begins by briefly introducing the preparation methods of SF-based hydrogel. Subsequently, the review summarizes diverse components loaded into the hydrogel to provide a comprehensive understanding in the antibacterial field. Furthermore, the article reviews the biomedical applications of antibacterial aspects including tissue engineering, sustained drug release, wound repair and adhesive use. Also the challenges associated with developing SF-based hydrogels are analyzed alongside future prospects. We hope that this study will contribute to promoting the application and innovation of SF material in the clinical antibacterial field. © 2024 Society of Chemical Industry.

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来源期刊
Polymer International
Polymer International 化学-高分子科学
CiteScore
7.10
自引率
3.10%
发文量
135
审稿时长
4.3 months
期刊介绍: Polymer International (PI) publishes the most significant advances in macromolecular science and technology. PI especially welcomes research papers that address applications that fall within the broad headings Energy and Electronics, Biomedical Studies, and Water, Environment and Sustainability. The Journal’s editors have identified these as the major challenges facing polymer scientists worldwide. The Journal also publishes invited Review, Mini-review and Perspective papers that address these challenges and others that may be of growing or future relevance to polymer scientists and engineers.
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