溅射制备纳米银聚丙交酯复合材料及其抗菌抗病毒应用

IF 2.9 4区 化学 Q2 POLYMER SCIENCE
Valeriy Demchenko, Yevgen Mamunya, Illia Sytnyk, Maksym Iurzhenko, Igor Krivtsun, Nataliya Rybalchenko, Krystyna Naumenko, Liubov Artiukh, Marek Kowalczuk, Olena Demchenko, Andrii Marynin
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引用次数: 0

摘要

研究了在聚乳酸(PLA)薄膜表面溅射沉积的含银复合材料;它们含有一层不同厚度的银纳米颗粒,这取决于沉积时间,即1、3和5分钟。结果表明,沉积时间为5 min,可形成厚度约为100 nm的薄膜。银纳米粒子的平均尺寸为5.9 nm,平均比表面积Ssp为97 m2 g−1。通过广角x射线散射、透射电镜、热重分析和差热分析对样品进行了表征,并对其抗菌、抗病毒和细胞毒性进行了研究。结果表明,最薄的银层(沉积1 min)对PLA的耐热性和玻璃化转变温度的影响最大。溅射银沉积制备的PLA-Ag复合材料对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌的抑菌活性均有所提高,且随溅射银沉积时间的延长而增强。经镀银5 min形成的PLA-Ag复合材料对1型单纯疱疹病毒和a型流感病毒有弱的杀病毒作用,而不考虑镀银时间,得到的复合材料没有细胞毒性;在1:10及以上稀释时,它们对MDCK、BHK和Hep-2细胞的活性没有明显的抑制作用。©2025化学工业协会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Fabrication of polylactide composites with silver nanoparticles by sputtering deposition and their antimicrobial and antiviral applications

Fabrication of polylactide composites with silver nanoparticles by sputtering deposition and their antimicrobial and antiviral applications

Silver-containing composites formed by sputtering deposition on the surface of polylactide (PLA) films have been developed; they contain a layer of silver nanoparticles of different thicknesses depending on the deposition time, namely 1, 3 and 5 min. It was found that with a deposition time of 5 min a layer with a thickness of ca 100 nm is formed. The average size of the Ag nanoparticles is 5.9 nm, and the average specific surface area Ssp is 97 m2 g−1. The samples obtained were characterized by wide-angle X-ray scattering, TEM, TGA and DSC and their antimicrobial, antiviral and cytotoxic properties were studied as well. It was found that the thinnest layer of silver (deposited for 1 min) has the greatest effect on the PLA's heat resistance and glass transition temperature. PLA-Ag composites formed by silver sputtering deposition show antimicrobial activity against the studied test cultures of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, and the activity of the samples increases with increasing duration of silver deposition. PLA-Ag composites formed by silver deposition for 5 min had a weak virucidal effect against herpes simplex virus type 1 and influenza virus type A. Irrespective of the sputtering time of silver the composites obtained were not cytotoxic; at a dilution of 1:10 and more they did not significantly inhibit the viability of MDCK, BHK and Hep-2 cells. © 2025 Society of Chemical Industry.

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来源期刊
Polymer International
Polymer International 化学-高分子科学
CiteScore
7.10
自引率
3.10%
发文量
135
审稿时长
4.3 months
期刊介绍: Polymer International (PI) publishes the most significant advances in macromolecular science and technology. PI especially welcomes research papers that address applications that fall within the broad headings Energy and Electronics, Biomedical Studies, and Water, Environment and Sustainability. The Journal’s editors have identified these as the major challenges facing polymer scientists worldwide. The Journal also publishes invited Review, Mini-review and Perspective papers that address these challenges and others that may be of growing or future relevance to polymer scientists and engineers.
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